AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 258: L81-L88, 1990;
1040-0605/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baraniuk, J. N.
Right arrow Articles by Kaliner, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baraniuk, J. N.
Right arrow Articles by Kaliner, M. A.

AJP - Lung Cellular and Molecular Physiology, Vol 258, Issue 2 81-L88, Copyright © 1990 by American Physiological Society

ARTICLES

Calcitonin gene-related peptide in human nasal mucosa

J. N. Baraniuk, J. D. Lundgren, J. Goff, J. Mullol, S. Castellino, M. Merida, J. H. Shelhamer and M. A. Kaliner
Allergic Diseases Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892.

To explore the potential range of functions for calcitonin gene-related peptide (CGRP) in human mucosa, we quantified human inferior turbinate nasal mucosal CGRP content by radioimmunoassay, localized CGRP-immunoreactivity by immunohistochemistry, detected 125I-CGRP binding sites by autoradiography, and tested the ability of CGRP to induce submucosal gland secretion in short-term explant culture of human nasal mucosa. Nasal mucosa contained 0.45-0.54 pmol CGRP/g wet wt (n = 18). Immunoreactive CGRP was found in nerve fibers that densely innervated the walls of small muscular arteries arterioles. Venules and venous sinusoids were innervated by individual CGRP staining fibers. Occasional CGRP-containing nerve fibers were also noted adjacent to submucosal gland acini, near the epithelial basement membrane, and between epithelial cells. Specific 125I-CGRP binding sites were concentrated on small muscular arteries and arterioles. CGRP (4 microM) did not stimulate glycoconjugate or lactoferrin release from mucosal explants. These results indicate that in the human nasal mucosa, CGRP is present in nerve fibers, which most likely represent nociceptive sensorimotor nerves that innervate vascular structures (muscular arteries, arterioles, veins and venous sinusoids). It is likely that CGRP release from sensory neurons may play a role in the regulation of vasomotor responses, but no evidence for a role of CGRP in glandular secretion was found.


This article has been cited by other articles:


Home page
 PhysiologyHome page
B. F. Bessac and S.-E. Jordt
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Physiology, December 1, 2008; 23(6): 360 - 370.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. M. Baroody, A. Gungor, M. deTineo, L. Haney, C. Blair, and R. M. Naclerio
Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine
J Appl Physiol, September 1, 1999; 87(3): 1038 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Rouadi, F. M. Baroody, D. Abbott, E. Naureckas, J. Solway, and R. M. Naclerio
A technique to measure the ability of the human nose to warm and humidify air
J Appl Physiol, July 1, 1999; 87(1): 400 - 406.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online