AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 259: L159-L184, 1990;
1040-0605/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crouch, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crouch, E.

AJP - Lung Cellular and Molecular Physiology, Vol 259, Issue 4 159-L184, Copyright © 1990 by American Physiological Society

ARTICLES

Pathobiology of pulmonary fibrosis

E. Crouch
Department of Pathology, Jewish Hospital of St. Louis, Washington University Medical Center, Missouri 63110.

Pulmonary fibrosis is characterized by an increase in lung matrix and alterations in the numbers and spatial relationships of lung parenchymal cells. The increase in matrix results from a proliferation and "activation" of fibroblasts (FB) with increased production and deposition of matrix macromolecules at sites of lung injury. Connective tissue cell activation is associated with increased gene expression of collagens, fibronectin, proteoglycans and other matrix components; cytoskeletal alterations; and probably also with changes in the expression of matrix receptors and matrix-degrading enzymes and inhibitors. The fibroproliferative reaction involves the participation of a variety of cytokines and inflammatory mediators by resident and inflammatory cells at sites of lung injury. Thickening of the alveolar wall can result secondary to matrix deposition within the interstitium and as a result of "mural incorporation" of organized airspace exudate. However, marked structural remodeling of the gas-exchange tissues, with the development of honeycomb lung, involves airspace fibrosis and alveolar collapse. The latter processes lead to areas of airspace obliteration secondary to airspace filling, and to fibrous adhesion of collapsed septa. The extent of airspace obliteration is determined largely by the severity or extent of epithelial injury. Although lung fibrosis is usually irreversible, the activated state is reversible after clearance of exudate and reepithelialization. A continuing and seemingly autonomous fibroproliferative reaction can result in the face of ongoing injury and delayed repair.


This article has been cited by other articles:


Home page
 Chronic Respiratory DiseaseHome page
M Ghanei, I Adibi, F Farhat, and J Aslani
Late respiratory effects of sulfur mustard: how is the early symptoms severity involved?
Chronic Respiratory Disease, May 1, 2008; 5(2): 95 - 100.
[Abstract] [PDF]

Home page
 Proc Am Thorac SocHome page
F. Chua and G. J. Laurent
Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.
Proceedings of the ATS, July 1, 2006; 3(5): 424 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Aghanouri, M. Ghanei, J. Aslani, H. Keivani-Amine, F. Rastegar, and A. Karkhane
Fibrogenic cytokine levels in bronchoalveolar lavage aspirates 15 years after exposure to sulfur mustard
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1160 - L1164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Murakami, N. Nagaya, T. Itoh, T. Fujii, T. Iwase, K. Hamada, H. Kimura, and K. Kangawa
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1172 - L1177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Venkatesan, L. Pini, and M. S. Ludwig
Changes in Smad expression and subcellular localization in bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1342 - L1347.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. R. Burns, C. W. Smith, and D. C. Walker
Unique Structural Features That Influence Neutrophil Emigration Into the Lung
Physiol Rev, April 1, 2003; 83(2): 309 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Pardo, V. Ruiz, J. L. Arreola, R. Ramirez, J. Cisneros-Lira, M. Gaxiola, R. Barrios, S. V. Kala, M. W. Lieberman, and M. Selman
Bleomycin-induced Pulmonary Fibrosis Is Attenuated in {gamma}-Glutamyl Transpeptidase-Deficient Mice
Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 925 - 932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. S. Warshamana, D. A. Pociask, P. Sime, D. A. Schwartz, and A. R. Brody
Susceptibility to Asbestos-Induced and Transforming Growth Factor-{beta}1-Induced Fibroproliferative Lung Disease in Two Strains of Mice
Am. J. Respir. Cell Mol. Biol., December 1, 2002; 27(6): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Venkatesan, P. J. Roughley, and M. S. Ludwig
Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta 1 and interferon-gamma
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L806 - L814.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Ghosh, T. Mendoza, L. A. Ortiz, G. W. Hoyle, C. D. Fermin, A. R. Brody, M. Friedman, and G. F. Morris
Bleomycin Sensitivity of Mice Expressing Dominant-Negative p53 in the Lung Epithelium
Am. J. Respir. Crit. Care Med., September 15, 2002; 166(6): 890 - 897.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. K. Haston, X. Zhou, L. Gumbiner-Russo, R. Irani, R. Dejournett, X. Gu, M. Weil, C. I. Amos, and E. L. Travis
Universal and Radiation-specific Loci Influence Murine Susceptibility to Radiation-induced Pulmonary Fibrosis
Cancer Res., July 1, 2002; 62(13): 3782 - 3788.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Razani, X. B. Wang, J. A. Engelman, M. Battista, G. Lagaud, X. L. Zhang, B. Kneitz, H. Hou Jr., G. J. Christ, W. Edelmann, et al.
Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae
Mol. Cell. Biol., April 1, 2002; 22(7): 2329 - 2344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Takahashi, K. Takahashi, T. Okazaki, K. Maeda, H. Ienaga, M. Maeda, S. Kon, T. Uede, and Y. Fukuchi
Role of Osteopontin in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., March 1, 2001; 24(3): 264 - 271.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
O. EICKELBERG, A. PANSKY, E. KOEHLER, M. BIHL, M. TAMM, P. HILDEBRAND, A. P. PERRUCHOUD, M. KASHGARIAN, and M. ROTH
Molecular mechanisms of TGF-{beta} antagonism by interferon {gamma} and cyclosporine A in lung fibroblasts
FASEB J, March 1, 2001; 15(3): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Krishna, K. Liu, H. Shigemitsu, M. Gao, T. A. Raffin, and G. D. Rosen
PG490-88, a Derivative of Triptolide, Blocks Bleomycin-Induced Lung Fibrosis
Am. J. Pathol., March 1, 2001; 158(3): 997 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Guo, C. Martinez-Williams, C. E. Yellowley, H. J. Donahue, and D. E. Rannels
Connexin expression by alveolar epithelial cells is regulated by extracellular matrix
Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L191 - L202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. MIKI, T. MIO, S. NAGAI, Y. HOSHINO, T. NAGAO, M. KITAICHI, and T. IZUMI
Fibroblast Contractility . Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2259 - 2264.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. DOHI, T. HASEGAWA, K. YAMAMOTO, and B. C. MARSHALL
Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2302 - 2307.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Shimizu, E. C. Gabazza, T. Hayashi, M. Ido, Y. Adachi, and K. Suzuki
Thrombin stimulates the expression of PDGF in lung epithelial cells
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L503 - L510.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Selman, V. Ruiz, S. Cabrera, L. Segura, R. Ramirez, R. Barrios, and A. Pardo
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L562 - L574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. M. Swaisgood, E. L. French, C. Noga, R. H. Simon, and V. A. Ploplis
The Development of Bleomycin-Induced Pulmonary Fibrosis in Mice Deficient for Components of the Fibrinolytic System
Am. J. Pathol., July 1, 2000; 157(1): 177 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. VENKATESAN, T. EBIHARA, P. J. ROUGHLEY, and M. S. LUDWIG
Alterations in Large and Small Proteoglycans in Bleomycin-Induced Pulmonary Fibrosis in Rats
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 2066 - 2073.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Vivekananda, V. Awasthi, S. Awasthi, D. B. Smith, and R. J. King
Hepatocyte growth factor is elevated in chronic lung injury and inhibits surfactant metabolism
Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L382 - L392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Miki, T. Mio, S. Nagai, Y. Hoshino, T. Tsutsumi, T. Mikuniya, and T. Izumi
Glucocorticoid-induced contractility and F-actin content of human lung fibroblasts in three-dimensional culture
Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L13 - L18.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Nagahori, M. Dohi, K. Matsumoto, K. Saitoh, Z.-I. Honda, T. Nakamura, and K. Yamamoto
Interferon-gamma Upregulates the c-Met/Hepatocyte Growth Factor Receptor Expression in Alveolar Epithelial Cells
Am. J. Respir. Cell Mol. Biol., October 1, 1999; 21(4): 490 - 497.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
I. Y. R. Adamson and J. Bakowska
Relationship of Keratinocyte Growth Factor and Hepatocyte Growth Factor Levels in Rat Lung Lavage Fluid to Epithelial Cell Regeneration after Bleomycin
Am. J. Pathol., September 1, 1999; 155(3): 949 - 954.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. B. Toews
Cellular Alterations in Fibroproliferative Lung Disease
Chest, July 1, 1999; 116(2007): 112S - 116S.
[Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Eickelberg, E. Kohler, F. Reichenberger, S. Bertschin, T. Woodtli, P. Erne, A. P. Perruchoud, and M. Roth
Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta 1 and TGF-beta 3
Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L814 - L824.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. M. Brass, G. W. Hoyle, H. G. Poovey, J.-Y. Liu, and A. R. Brody
Reduced Tumor Necrosis Factor-{alpha} and Transforming Growth Factor-ß1 Expression in the Lungs of Inbred Mice that Fail to Develop Fibroproliferative Lesions Consequent to Asbestos Exposure
Am. J. Pathol., March 1, 1999; 154(3): 853 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J.-Y. Liu, D. M. Brass, G. W. Hoyle, and A. R. Brody
TNF-{alpha} Receptor Knockout Mice Are Protected from the Fibroproliferative Effects of Inhaled Asbestos Fibers
Am. J. Pathol., December 1, 1998; 153(6): 1839 - 1847.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. W. Peterson and J. Kirschbaum
Asbestos-induced lung epithelial permeability: potential role of nonoxidant pathways
Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L262 - L268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Zhao, S. L. Young, and J. C. McIntosh
Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1049 - L1057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. J. Mariani, S. E. Dunsmore, Q. Li, X. Ye, and R. A. Pierce
Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, January 1, 1998; 274(1): L47 - L57.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. N. CHESNUTT, M. A. MATTHAY, F. A. TIBAYAN, and J. G. CLARK
Early Detection of Type III Procollagen Peptide in Acute Lung Injury . Pathogenetic and Prognostic Significance
Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 840 - 845.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online