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Am J Physiol Lung Cell Mol Physiol 260: L207-L211, 1991;
1040-0605/91 $5.00
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AJP - Lung Cellular and Molecular Physiology, Vol 260, Issue 4 207-L211, Copyright © 1991 by American Physiological Society

ARTICLES

Interactions of oxidant stress and vascular reactivity

G. H. Gurtner and T. Burke-Wolin
Department of Medicine, New York Medical College, Valhalla 10595.

Oxidants have complex effects on pulmonary vascular reactivity. They can stimulate production of vasoconstrictor arachidonate mediators and can also cause vasodilation through activation of guanylate cyclase. Oxidants can also inactivate vasomotor phenomenon by interfering with mechanisms of signal transduction or smooth muscle contraction. The final physiological response depends on the balance of these complex actions.


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