AJP - Lung AJP: Cell Physiology
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Am J Physiol Lung Cell Mol Physiol 261: L21-L22, 1991;
1040-0605/91 $5.00
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A 90-kDa surface antigen of immature smooth muscle cells is ICAM-1

O. Yu. Printseva 1, M. M. Peclo 1, A. V. Tjurmin 1, and A. M. Gown 1

1 Institute of Experimental Cardiology and Cardiology Research Center, Moscow 121552, USSR; and Department of Pathology, University of Washington, Seattle, Washington 98195

A monoclonal antibody, designated 10F3, that reacts with an antigen of molecular mass 90,000 Da has been developed by immunization of BALB/c mice with smooth muscle cells in long-term culture. The cells were originally isolated from fetal human aorta. The 10F3 was identified as an antibody that reacts with the ICAM-1 molecule. ICAM-1 is a mesenchymal antigen that is lost during differentiation of cells other than endothelium but is reexpressed by the intimal cells of vessels involved in atherogenesis.

atherosclerosis; monoclonal antibodies






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