AJP - Lung AJP: Regulatory, Integrative and Comparative Physiology
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Am J Physiol Lung Cell Mol Physiol 261: L72-L77, 1991;
1040-0605/91 $5.00
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Expression of cytokeratin 8 in human aortic smooth muscle cells

Marina A. Glukhova 1, Boris V. Shekhonin 1, Howard Kruth 1, and Victor E. Koteliansky 1

1 Institute of Experimental Cardiology, USSR Cardiology Research Center, 121552 Moscow, USSR; and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892

An immunofluorescence method was used to study the expression of cytokeratin 8 in human aortic smooth muscle cells (SMCs) during prenatal development and in atherosclerotic plaques. Aortic SMCs from a 10-wk-old fetus contained cytokeratin 8 in additional to vimentin and a small amount of desmin, whereas, in the cells from a 25-wk-old fetus, cytokeratin 8 was not detected. Cytokeratin 8 was found in the SMCs from intimal thickenings, fatty streaks, and atherosclerotic fibrous plaques. Clusters of cytokeratin 8-positive cells were more abundant in rather advanced lesions (fibrous plaques) that contained at least some amount of lipid. Expression of cytokeratin 8 in the cells of human atherosclerotic lesions probably reflects general rearrangement of gene expression in the intimal cells.

cytodifferentiation; fetal phenotype; lipid accumulation






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