AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 262: L412-L417, 1992;
1040-0605/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pison, U.
Right arrow Articles by Hawgood, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pison, U.
Right arrow Articles by Hawgood, S.

AJP - Lung Cellular and Molecular Physiology, Vol 262, Issue 4 412-L417, Copyright © 1992 by American Physiological Society

ARTICLES

Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages

U. Pison, J. R. Wright and S. Hawgood
Cardiovascular Research Institute, University of California, San Francisco 94143.

Surfactant protein A (SP-A) influences the function of alveolar macrophages in vitro. In this study the characteristics of the binding of 125I-labeled SP-A to rat alveolar macrophages has been investigated. The binding of SP-A to alveolar macrophages at 4 degrees C was saturable with half-maximal binding at a SP-A concentration of 4 micrograms/ml. Bound SP-A was rapidly displaced by an excess of unlabeled SP-A. The binding of labeled SP-A to the alveolar macrophages was blocked in a dose-dependent fashion by unlabeled SP-A, the collagen-like protein C1q and type V collagen but not by bovine serum albumin. These results suggest that a component of the interaction between SP-A and alveolar macrophages is mediated through the collagen-like domain of SP-A and that the characteristics of this interaction are consistent with there being a specific receptor for SP-A on the surface of alveolar macrophages.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. C. Malherbe, V. J. Erpenbeck, S. N. Abraham, E. C. Crouch, J. M. Hohlfeld, and J. R. Wright
Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L856 - L866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. J. Erpenbeck, D. C. Malherbe, S. Sommer, A. Schmiedl, W. Steinhilber, A. J. Ghio, N. Krug, J. R. Wright, and J. M. Hohlfeld
Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L692 - L698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. L. Schagat, J. A. Wofford, K. E. Greene, and J. R. Wright
Surfactant protein A differentially regulates peripheral and inflammatory neutrophil chemotaxis
Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L140 - L147.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Beharka, C. D. Gaynor, B. K. Kang, D. R. Voelker, F. X. McCormack, and L. S. Schlesinger
Pulmonary Surfactant Protein A Up-Regulates Activity of the Mannose Receptor, a Pattern Recognition Receptor Expressed on Human Macrophages
J. Immunol., October 1, 2002; 169(7): 3565 - 3573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Stamme, M. Muller, L. Hamann, T. Gutsmann, and U. Seydel
Surfactant Protein A Inhibits Lipopolysaccharide-Induced Immune Cell Activation by Preventing the Interaction of Lipopolysaccharide with Lipopolysaccharide-Binding Protein
Am. J. Respir. Cell Mol. Biol., September 1, 2002; 27(3): 353 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. A. Quintero, T. R. Korfhagen, and J. R. Wright
Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L76 - L85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Yoshida, M. Ikegami, J. A. Reed, Z. C. Chroneos, and J. A. Whitsett
GM-CSF regulates protein and lipid catabolism by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L379 - L386.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. LeVine, J. A. Whitsett, J. A. Gwozdz, T. R. Richardson, J. H. Fisher, M. S. Burhans, and T. R. Korfhagen
Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung
J. Immunol., October 1, 2000; 165(7): 3934 - 3940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Baritussio, A. Alberti, D. Armanini, F. Meloni, and D. Bruttomesso
Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L91 - L99.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. W. Spech, P. Wisniowski, D. L. Kachel, J. R. Wright, and W. J. Martin II
Surfactant protein A prevents silica-mediated toxicity to rat alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L713 - L718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. F. Herbein, J. Savov, and J. R. Wright
Binding and uptake of surfactant protein D by freshly isolated rat alveolar type II cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L830 - L839.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. L. Schagat, M. J. Tino, and J. R. Wright
Regulation of Protein Phosphorylation and Pathogen Phagocytosis by Surfactant Protein A
Infect. Immun., September 1, 1999; 67(9): 4693 - 4699.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. S. Harrod, B. C. Trapnell, K. Otake, T. R. Korfhagen, and J. A. Whitsett
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection
Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L580 - L588.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Sano, H. Sohma, T. Muta, S.-i. Nomura, D. R. Voelker, and Y. Kuroki
Pulmonary Surfactant Protein A Modulates the Cellular Response to Smooth and Rough Lipopolysaccharides by Interaction with CD14
J. Immunol., July 1, 1999; 163(1): 387 - 395.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Tino and J. R. Wright
Glycoprotein-340 Binds Surfactant Protein-A (SP-A) and Stimulates Alveolar Macrophage Migration in an SP-A-Independent Manner
Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 759 - 768.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Stamme and J. R. Wright
Surfactant protein A enhances the binding and deacylation of E. coli LPS by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L540 - L547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. M. LeVine, K. E. Kurak, J. R. Wright, W. T. Watford, M. D. Bruno, G. F. Ross, J. A. Whitsett, and T. R. Korfhagen
Surfactant Protein-A Binds Group B Streptococcus Enhancing Phagocytosis and Clearance from Lungs of Surfactant Protein-A-Deficient Mice
Am. J. Respir. Cell Mol. Biol., February 1, 1999; 20(2): 279 - 286.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Tino and J. R. Wright
Surfactant proteins A and D specifically stimulate directed actin-based responses in alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, January 1, 1999; 276(1): L164 - L174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Zhu, D. L. Kachel, W. J. Martin II, and S. Matalon
Nitrated SP-A does not enhance adherence of Pneumocystis carinii to alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1031 - L1039.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. M. LeVine, K. E. Kurak, M. D. Bruno, J. M. Stark, J. A. Whitsett, and T. R. Korfhagen
Surfactant Protein-A-Deficient Mice Are Susceptible to Pseudomonas aeruginosa Infection
Am. J. Respir. Cell Mol. Biol., October 1, 1998; 19(4): 700 - 708.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. C. Crouch
Collectins and Pulmonary Host Defense
Am. J. Respir. Cell Mol. Biol., August 1, 1998; 19(2): 177 - 201.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. J. Mason, K. Greene, and D. R. Voelker
Surfactant protein A and surfactant protein D in health and disease
Am J Physiol Lung Cell Mol Physiol, July 1, 1998; 275(1): L1 - L13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Alberti, F. Ravenna, D. Quaglino, M. Luisetti, M. Muraca, L. Previato, G. B. Enzi, R. Bruni, and A. Baritussio
In chyloptysis, SP-A affects the clearance of serum lipoproteins entering the airways
Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L737 - L749.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Sano, Y. Kuroki, T. Honma, Y. Ogasawara, H. Sohma, D. R. Voelker, and T. Akino
Analysis of Chimeric Proteins Identifies the Regions in the Carbohydrate Recognition Domains of Rat Lung Collectins That Are Essential for Interactions with Phospholipids, Glycolipids, and Alveolar Type II Cells
J. Biol. Chem., February 20, 1998; 273(8): 4783 - 4789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. M. Hickman-Davis, J. R. Lindsey, S. Zhu, and S. Matalon
Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, February 1, 1998; 274(2): L270 - L277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Dong and J. R. Wright
Degradation of surfactant protein D by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, January 1, 1998; 274(1): L97 - L105.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. R. Bates, J. Xu, C. Dodia, and A. B. Fisher
Macrophages primed by overnight culture demonstrate a marked stimulation of surfactant protein A degradation
Am J Physiol Lung Cell Mol Physiol, October 1, 1997; 273(4): L831 - L839.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Pasula, J. F. Downing, J. R. Wright, D. L. Kachel, T. E. Davis Jr., and W. J. Martin II
Surfactant Protein A (SP-A) Mediates Attachment of Mycobacterium tuberculosis to Murine Alveolar Macrophages
Am. J. Respir. Cell Mol. Biol., August 1, 1997; 17(2): 209 - 217.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Sano, H. Chiba, D. Iwaki, H. Sohma, D. R. Voelker, and Y. Kuroki
Surfactant Proteins A and D Bind CD14 by Different Mechanisms
J. Biol. Chem., July 14, 2000; 275(29): 22442 - 22451.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online