AJP - Lung Cellular and Molecular Physiology, Vol 264, Issue 4 345-L350, Copyright © 1993 by American Physiological Society
Effects of gastrin-releasing peptide and analogues on guinea pig nasal mucosal secretion
A. Z. Gawin, J. N. Baraniuk, J. D. Lundgren and M. Kaliner
Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
The effects of gastrin-releasing peptide (GRP), bombesin, GRP-(1-16) and
GRP-(21-27) on guinea pig nasal mucosal secretion were studied in vivo.
GRP, bombesin, and GRP-(21-27) induced significant secretion of total
protein, albumin, and alkaline phosphatase. GRP induced significant
secretion at lower concentrations (10(-11) and 10(-10) M) than were
required for bombesin and GRP-(21-27) (10(-7) M). GRP-(1-16) did not
stimulate secretion, indicating that the COOH-terminal region of GRP
contained the secretagogic principle. Capsaicin, a stimulant of nociceptive
sensory nerves, stimulated GRP release into nasal secretions. These data
suggest that GRP is present in guinea pig nasal mucosa and that the
COOH-terminal region of GRP may regulate mucosal macromolecule secretion.
