| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Lung Cellular and Molecular Physiology, Vol 264, Issue 4 406-L412, Copyright © 1993 by American Physiological Society
ARTICLES |
S. K. Lo, K. Janakidevi, L. Lai and A. B. Malik
Department of Physiology and Cell Biology, Albany Medical College, New York 12208.
Reactive oxygen radicals (ROS) generated by phagocytes promote human polymorphonuclear leukocyte (PMN) adhesion to human umbilical vein endothelial cells (EC). We determined the effects of hydrogen peroxide (H2O2), a phagocyte-derived ROS, on EC adhesiveness by determining steady-state intracellular adhesion molecule 1 (ICAM-1) mRNA and ICAM-1 protein expression. The adhesion of PMN to H2O2-treated EC was concentration dependent with maximal adhesion achieved at 0.1 mM H2O2. PMN adhesion occurred rapidly, reaching its maximum value within a 1-h treatment time. The PMN adhesion was dependent on the interaction between CD11/CD18 integrins on PMN and ICAM-1 on EC, since either anti-CD18 or anti-ICAM-1 monoclonal antibodies (MAbs) inhibited (by > 90%) the adhesive interaction between PMN and EC. In parallel with the increases in EC adhesivity, we detected a two- to threefold increase in EC surface expression of ICAM-1 between 0.5 and 1 h after H2O2 challenge. Northern analysis revealed an increase in the steady-state ICAM-1 mRNA signal within 0.5 h after H2O2 exposure, and the response was sustained up to 2 h. Inhibition of intracellular catalase in H2O2-treated EC by 3-amino-1,2,3-triazole augmented the PMN adhesion by 20%, whereas enhancement of EC H2O2-scavenging activity by addition of catalase abrogated the H2O2-induced PMN adhesion, indicating that oxidant-antioxidant balance at the EC interface is a critical factor modulating PMN-EC adhesive interactions. The results suggest that H2O2-induced PMN adhesion is dependent on the rapid induction of the ICAM-1 mRNA signal and the surface expression of ICAM-1 on EC.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  P. Qin, X. Tang, M. M. Elloso, and D. C. Harnish Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-{kappa}B, and p38 Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H741 - H747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhou, X.-P. Gao, J. Fan, Q. Liu, K. N. Anwar, R. S. Frey, and A. B. Malik LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L655 - L662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bertuglia and A. Giusti Microvascular oxygenation, oxidative stress, NO suppression and superoxide dismutase during postischemic reperfusion Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1064 - H1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Abiko, A. Abiko, A. C. Clermont, B. Shoelson, N. Horio, J. Takahashi, A. P. Adamis, G. L. King, and S.-E. Bursell Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation Diabetes, March 1, 2003; 52(3): 829 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sasaki, D. Ostanin, J. W. Elrod, T. Oshima, P. Jordan, M. Itoh, T. Joh, A. Minagar, and J. S. Alexander TNF-alpha -induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent Am J Physiol Cell Physiol, February 1, 2003; 284(2): C422 - C428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yasuda, S. Shimizu, K. Ohhinata, S. Naito, S. Tokuyama, Y. Mori, Y. Kiuchi, and T. Yamamoto Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis Am J Physiol Cell Physiol, April 1, 2002; 282(4): C917 - C925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yabe, N. Kobayashi, T. Nishihashi, R. Takahashi, M. Nishikawa, Y. Takakura, and M. Hashida Prevention of Neutrophil-Mediated Hepatic Ischemia/Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 894 - 899. [Abstract] [Full Text]
|
|
|
|
|
|
H. Lum and K. A. Roebuck Oxidant stress and endothelial cell dysfunction Am J Physiol Cell Physiol, April 1, 2001; 280(4): C719 - C741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Xu, A. Rahman, R. D. Minshall, C. Tiruppathi, and A. B. Malik {beta}2-Integrin Blockade Driven by E-Selectin Promoter Prevents Neutrophil Sequestration and Lung Injury in Mice Circ. Res., August 4, 2000; 87(3): 254 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Meilhac, M. Zhou, N. Santanam, and S. Parthasarathy Lipid peroxides induce expression of catalase in cultured vascular cells J. Lipid Res., August 1, 2000; 41(8): 1205 - 1213. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. KITAMURA The Antioxidant N-Acetylcysteine Induces Mesangial Cells to Create Three-Dimensional Cytoarchitecture That Underlies Cellular Differentiation J. Am. Soc. Nephrol., April 1, 1999; 10(4): 746 - 751. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kokura, R. E. Wolf, T. Yoshikawa, D. N. Granger, and T. Y. Aw Molecular Mechanisms of Neutrophil-Endothelial Cell Adhesion Induced by Redox Imbalance Circ. Res., March 19, 1999; 84(5): 516 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Bhunia, T. Arai, G. Bulkley, and S. Chatterjee Lactosylceramide Mediates Tumor Necrosis Factor-alpha -induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells J. Biol. Chem., December 18, 1998; 273(51): 34349 - 34357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ogura and M. Kitamura Oxidant Stress Incites Spreading of Macrophages via Extracellular Signal-Regulated Kinases and p38 Mitogen-Activated Protein Kinase J. Immunol., October 1, 1998; 161(7): 3569 - 3574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. De Kimpe, E. E. Änggård, and M. J. Carrier Reactive Oxygen Species Regulate Macrophage Scavenger Receptor Type I, but Not Type II, in the Human Monocytic Cell Line THP-1 Mol. Pharmacol., June 1, 1998; 53(6): 1076 - 1082. [Abstract] [Full Text]
|
|
|
|
|
|
N. Okayama, H. Ichikawa, L. Coe, M. Itoh, and J. S. Alexander Exogenous NO enhances hydrogen peroxide-mediated neutrophil adherence to cultured endothelial cells Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L820 - L826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Morise, S. Komatsu, J. W. Fuseler, D. N. Granger, M. Perry, A. C. Issekutz, and M. B. Grisham ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G246 - G252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lakshminarayanan, D. W. A. Beno, R. H. Costa, and K. A. Roebuck Differential Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 by H2O2 and Tumor Necrosis Factor-alpha in Endothelial and Epithelial Cells J. Biol. Chem., December 26, 1997; 272(52): 32910 - 32918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ichikawa, S. Flores, P. R. Kvietys, R. E. Wolf, T. Yoshikawa, D. N. Granger, and T. Y. Aw Molecular Mechanisms of Anoxia/Reoxygenation-Induced Neutrophil Adherence to Cultured Endothelial Cells Circ. Res., December 19, 1997; 81(6): 922 - 931. [Abstract] [Full Text]
|
|
|
|
 |
|
 J.J. Chiu, B.S. Wung, J. Y.J. Shyy, H.J. Hsieh, and D.L. Wang Reactive Oxygen Species Are Involved in Shear Stress-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3570 - 3577. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. B. Nathens, R. Bitar, C. Davreux, M. Bujard, J. C. Marshall, A. P. B. Dackiw, R. W. G. Watson, and O. D. Rotstein Pyrrolidine Dithiocarbamate Attenuates Endotoxin-induced Acute Lung Injury Am. J. Respir. Cell Mol. Biol., November 1, 1997; 17(5): 608 - 616. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Reignier, H. Sellak, R. Lemoine, A. Lubineau, G. M. Mazmanian, H. Detruit, A. Chapelier, P. Herve, and T. P.-S. U. L. T. Group Prevention of ischemia-reperfusion lung injury by sulfated Lewisa pentasaccharide J Appl Physiol, April 1, 1997; 82(4): 1058 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Terada, B. M. Hybertson, K. G. Connelly, D. Weill, D. Piermattei, and J. E. Repine XO increases neutrophil adherence to endothelial cells by a dual ICAM-1 and P-selectin-mediated mechanism J Appl Physiol, March 1, 1997; 82(3): 866 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fan, R. S. Frey, A. Rahman, and A. B. Malik Role of Neutrophil NADPH Oxidase in the Mechanism of Tumor Necrosis Factor-alpha -induced NF-kappa B Activation and Intercellular Adhesion Molecule-1 Expression in Endothelial Cells J. Biol. Chem., January 25, 2002; 277(5): 3404 - 3411. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
