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AJP - Lung Cellular and Molecular Physiology, Vol 265, Issue 1 1-12, Copyright © 1993 by American Physiological Society
ARTICLES |
L. Neckers and L. Whitesell
Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Antisense RNA and DNA techniques have been developed as a relatively recent approach to the specific modulation of gene expression in vitro and in vivo. This review discusses general considerations for the application of antisense techniques. We shall examine the relative advantages and disadvantages of DNA versus RNA techniques, as well as the common pitfalls peculiar to each strategy.
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