AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 265: L507-L511, 1993;
1040-0605/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertrand, C.
Right arrow Articles by Nadel, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertrand, C.
Right arrow Articles by Nadel, J. A.

AJP - Lung Cellular and Molecular Physiology, Vol 265, Issue 5 507-L511, Copyright © 1993 by American Physiological Society

ARTICLES

Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs

C. Bertrand, P. Geppetti, P. D. Graf, A. Foresi and J. A. Nadel
Cardiovascular Research Institute, University of California, San Francisco 94143-0130.

The role of tachykinins released from sensory nerves in bronchoconstriction induced by antigen was studied in sensitized guinea pigs anesthetized with pentobarbital sodium and pretreated with atropine. The combination of NK2 (SR-48968) and NK1 (CP-96,345) tachykinin-receptor antagonists abolished the increase in total pulmonary resistance (RL) evoked by intravenous capsaicin but did not affect the response evoked by intravenous histamine. A small dose of aerosolized ovalbumin (OVA, 0.1%) produced a small increase in RL that was further increased and markedly prolonged by the neutral endopeptidase (NEP) inhibitor phosphoramidon; this bronchoconstrictor effect of OVA was markedly reduced by the NK2-receptor antagonist and was abolished by the combination of the NK1 and NK2-receptor antagonists together. When a larger dose of OVA (0.5%) was used, a maximal bronchoconstrictor response was obtained. Phosphoramidon did not potentiate this response significantly. The combination of NK1- and NK2-receptor antagonists blunted the response at 5 min only slightly but markedly attenuated the later (10-20 min) response. These results show that tachykinins released from sensory nerves play a significant role in antigen-induced bronchoconstriction in guinea pigs. This effect is exaggerated when the normal modulation of neuropeptides by NEP is inhibited and is mediated predominantly by NK2-receptor activation, with a smaller contribution by NK1 receptors.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
Z.-X. WU, D. ZHOU, G. CHEN, and L.-Y. LEE
Airway Hyperresponsiveness to Cigarette Smoke in Ovalbumin-sensitized Guinea Pigs
Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 73 - 80.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Katsunuma, A. F. Roffel, C. R. S. Elzinga, J. Zaagsma, P. J. Barnes, and J. C. W. Mak
beta 2-Adrenoceptor Agonist-Induced Upregulation of Tachykinin NK2 Receptor Expression and Function in Airway Smooth Muscle
Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 409 - 417.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. SCHUILING, A. B. ZUIDHOF, J. ZAAGSMA, and H. MEURS
Involvement of Tachykinin NK1 Receptor in the Development of Allergen-induced Airway Hyperreactivity and Airway Inflammation in Conscious, Unrestrained Guinea Pigs
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 423 - 430.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online