| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Lung Cellular and Molecular Physiology, Vol 266, Issue 3 308-L315, Copyright © 1994 by American Physiological Society
ARTICLES |
N. S. Hill, J. R. Klinger, R. R. Warburton, L. Pietras and D. S. Wrenn
Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, Providence.
To test the hypothesis that brain natriuretic peptide (BNP) plays a role similar to that of atrial natriuretic peptide (ANP) in modulating pulmonary vascular responses to hypoxia, we measured the vasodilator potency of ANP and BNP in rat pulmonary artery (PA) and thoracic aorta (TA) rings and in isolated rat lungs. We also measured the effect of chronic hypoxia on plasma levels and cardiac gene expression of both peptides. BNP had a vasorelaxant effect equipotent to that of ANP on preconstricted TA and PA rings, but was less potent than ANP in relaxing the vasoconstrictor response to hypoxia in isolated lungs [mean 50% inhibitory concentration (IC50) 10(-7) vs. 10(-6) M for ANP and BNP, respectively]. Plasma BNP levels were 30-fold lower than ANP, but both peptides increased approximately 70% during chronic hypoxia. In the right atrium, hypoxia lowered BNP mRNA slightly, but had no effect on ANP mRNA or tissue levels of either peptide. However, hypoxia increased right ventricular content and mRNA levels of both peptides by three- to fourfold. We conclude that BNP and ANP have similar pulmonary vasodilator effects and are upregulated proportionally during chronic hypoxia. These results support a role for BNP in modulating the pulmonary hypertensive response to chronic hypoxia.
This article has been cited by other articles:
|
|
 |
|
  K. Nakanishi, H. Osada, M. Uenoyama, F. Kanazawa, N. Ohrui, Y. Masaki, T. Hayashi, Y. Kanatani, T. Ikeda, and T. Kawai Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2159 - H2168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Klinger, R. R. Warburton, L. Pietras, P. Oliver, J. Fox, O. Smithies, and N. S. Hill Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H58 - H65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Klinger, L. Pietras, R. Warburton, and N. S. Hill Reduced Oxygen Tension Increases Atrial Natriuretic Peptide Release from Atrial Cardiocytes Experimental Biology and Medicine, October 1, 2001; 226(9): 847 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Z. Sun, S.-J. Chen, G. Li, and Y.-F. Chen Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout mice Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L511 - L519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V E Hjortdal, E V Stenbøg, H B Ravn, K Emmertsen, K T Jensen, E B Pedersen, K H Olsen, O K Hansen, and K E Sørensen Neurohormonal activation late after cavopulmonary connection Heart, April 1, 2000; 83(4): 439 - 443. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Kodama and H. Adachi Improvement of Mortality by Long-Term E4010 Treatment in Monocrotaline-Induced Pulmonary Hypertensive Rats J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 748 - 752. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Salameh, M. R. Karamsetty, R. R. Warburton, J. R. Klinger, L. C. Ou, and N. S. Hill Differences in acute hypoxic pulmonary vasoresponsiveness between rat strains: role of endothelium J Appl Physiol, July 1, 1999; 87(1): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Klinger, R. R. Warburton, L. A. Pietras, O. Smithies, R. Swift, and N. S. Hill Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L868 - L874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Klinger, F. M. Siddiq, R. A. Swift, C. Jackson, L. Pietras, R. R. Warburton, C. Alia, and N. S. Hill C-type natriuretic peptide expression and pulmonary vasodilation in hypoxia-adapted rats Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L645 - L652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Klinger, R. R. Warburton, L. Pietras, and N. S. Hill Brain natriuretic peptide inhibits hypoxic pulmonary hypertension in rats J Appl Physiol, May 1, 1998; 84(5): 1646 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishikimi, S. Nagata, T. Sasaki, S. Tomimoto, H. Matsuoka, S. Takishita, K. Kitamura, A. Miyata, H. Matsuo, and K. Kangawa Plasma concentrations of adrenomedullin correlate with the extent of pulmonary hypertension in patients with mitral stenosis Heart, October 1, 1997; 78(4): 390 - 395. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
