AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 266: L436-L447, 1994;
1040-0605/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baritussio, A.
Right arrow Articles by Pasquali-Ronchetti, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baritussio, A.
Right arrow Articles by Pasquali-Ronchetti, I.

AJP - Lung Cellular and Molecular Physiology, Vol 266, Issue 4 436-L447, Copyright © 1994 by American Physiological Society

ARTICLES

SP-A, SP-B, and SP-C in surfactant subtypes around birth: reexamination of alveolar life cycle of surfactant

A. Baritussio, A. Alberti, D. Quaglino, A. Pettenazzo, D. Dalzoppo, L. Sartori and I. Pasquali-Ronchetti
Istituti di Medicina Interna, Pediatria e Chimica Organica, Universita' di Padova, Italy.

Transformations of surfactant after secretion are incompletely understood. To clarify them, we lavaged lungs in fetuses and in newborn rabbits, fractionated the lavage fluid by differential and density gradient centrifugation, and analyzed the distribution of surfactant protein (SP) phospholipids, SP-A, SP-B, and SP-C. Furthermore, we administered into trachea of newborn rabbits labeled surfactant and compared the alveolar clearance of SP-A, SP-B, SP-C and saturated phosphatidylcholine. We found that, in the fetus, secreted lamellar bodies contain all components of surfactant, except a small amount of SP-A. As breathing starts and new surfactant subtypes are generated, the proteins are mostly associated with dense subtypes, but SP-B and SP-C are especially concentrated in dense materials that contain minor amounts of phospholipids and SP-A. Furthermore, we found that, during breathing, alveolar surfactant is degraded into more than one type of remnant, that the lavage fluid contains a pool of SP-A not associated with membranes, and that SP-A, SP-B, and SP-C are all turned over at a faster rate than saturated phosphatidylcholine.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Wofford and J. R. Wright
Surfactant protein A regulates IgG-mediated phagocytosis in inflammatory neutrophils
Am J Physiol Lung Cell Mol Physiol, December 1, 2007; 293(6): L1437 - L1443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. L. H. Poelma, L. J. Zimmermann, W. A. van Cappellen, J. J. Haitsma, B. Lachmann, and J. F. van Iwaarden
Distinct effects of SP-B and SP-C on the uptake of surfactant-like liposomes by alveolar cells in vivo and in vitro
Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L1056 - L1065.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. G. Vazquez de Lara, T. M. Umstead, S. E. Davis, and D. S. Phelps
Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L899 - L906.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Maestrelli, C. Paska, M. Saetta, G. Turato, Y. Nowicki, S. Monti, B. Formichi, M. Miniati, and L.M. Fabbri
Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients
Eur. Respir. J., June 1, 2003; 21(6): 971 - 976.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. E. Cogo, L. J. I. Zimmermann, F. Rosso, F. Tormena, P. Gamba, G. Verlato, A. Baritussio, and V. P. Carnielli
Surfactant Synthesis and Kinetics in Infants with Congenital Diaphragmatic Hernia
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 154 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Ochs, G. Johnen, K.-M. Muller, T. Wahlers, S. Hawgood, J. Richter, and F. Brasch
Intracellular and Intraalveolar Localization of Surfactant Protein A (SP-A) in the Parenchymal Region of the Human Lung
Am. J. Respir. Cell Mol. Biol., January 1, 2002; 26(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Baritussio, S. Marzini, M. Agostini, A. Alberti, C. Cimenti, D. Bruttomesso, E. Manzato, D. Quaglino, and A. Pettenazzo
Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1189 - L1199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. MAESTRELLI, A. H. EL MESSLEMANI, O. DE FINA, Y. NOWICKI, M. SAETTA, C. MAPP, and L. M. FABBRI
Increased Expression of Heme Oxygenase (HO)-1 in Alveolar Spaces and HO-2 in Alveolar Walls of Smokers
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1508 - 1513.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. GROSS, M. KELLAM, J. YOUNG, S. KRISHNASAMY, and R. DHAND
Separation of Alveolar Surfactant into Subtypes . A Comparison of Methods
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Baritussio, A. Alberti, D. Armanini, F. Meloni, and D. Bruttomesso
Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L91 - L99.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Savov, J. R. Wright, and S. L. Young
Incorporation of biotinylated SP-A into rat lung surfactant layer, type II cells, and Clara cells
Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L118 - L126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. F. Ross, M. Ikegami, W. Steinhilber, and A. H. Jobe
Surfactant protein C in fetal and ventilated preterm rabbit lungs
Am J Physiol Lung Cell Mol Physiol, December 1, 1999; 277(6): L1104 - L1108.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Rosseau, P. Hammerl, U. Maus, A. Gunther, W. Seeger, F. Grimminger, and J. Lohmeyer
Surfactant Protein A Down-Regulates Proinflammatory Cytokine Production Evoked by Candida albicans in Human Alveolar Macrophages and Monocytes
J. Immunol., October 15, 1999; 163(8): 4495 - 4502.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Savov, R. Silbajoris, and S. L. Young
Mechanical ventilation of rat lung: effect on surfactant forms
Am J Physiol Lung Cell Mol Physiol, August 1, 1999; 277(2): L320 - L326.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. BELAI, J. M. HERNÁNDEZ-JUVIEL, R. BRUNI, A. J. WARING, and F. J. WALTHER
Addition of alpha 1-Antitrypsin to Surfactant Improves Oxygenation in Surfactant-deficient Rats
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 917 - 923.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Stamme and J. R. Wright
Surfactant protein A enhances the binding and deacylation of E. coli LPS by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L540 - L547.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Oulton, E. Edwards, and K. Handa
Convertase activity in alveolar surfactant and lamellar bodies in fetal, newborn, and adult rabbits
J Appl Physiol, January 1, 1999; 86(1): 71 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Tino and J. R. Wright
Surfactant proteins A and D specifically stimulate directed actin-based responses in alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, January 1, 1999; 276(1): L164 - L174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Ikegami, T. R. Korfhagen, J. A. Whitsett, M. D. Bruno, S. E. Wert, K. Wada, and A. H. Jobe
Characteristics of surfactant from SP-A-deficient mice
Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L247 - L254.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Ikegami, A. D. Horowitz, J. A. Whitsett, and A. H. Jobe
Clearance of SP-C and recombinant SP-C in vivo and in vitro
Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L933 - L939.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Alberti, F. Ravenna, D. Quaglino, M. Luisetti, M. Muraca, L. Previato, G. B. Enzi, R. Bruni, and A. Baritussio
In chyloptysis, SP-A affects the clearance of serum lipoproteins entering the airways
Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L737 - L749.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
F. Barr, H. Clark, and S. Hawgood
Identification of a putative surfactant convertase in rat lung as a secreted serine carboxylesterase
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L404 - L410.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online