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Am J Physiol Lung Cell Mol Physiol 275: L1026-L1030, 1998;
1040-0605/98 $5.00
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Vol. 275, Issue 6, L1026-L1030, December 1998

Effects of initial length on intrinsic tone in guinea pig tracheal smooth muscle

Martin Bard1, Sergio Salmeron1, Catherine Coirault2, Francois-Xavier Blanc2, and Yves Lecarpentier2,3

1 Unité de Pneumologie, Service de Médecine Interne, and 3 Service de Physiologie Cardio-Respiratoire, Hôpital Universitaire Bicêtre, 94275 Le Kremlin-Bicêtre; and 2 Laboratoire d'Optique Appliquée, École Nationale Supérieure de Techniques Avancées-Ecole Polytechnique, Institut National de la Santé et de la Recherche Médicale Unité 451, 91125 Palaiseau, France

In the guinea pig, tracheal smooth muscle (TSM) exhibits intrinsic tone (IT). The active nature of IT suggests that it could be influenced by muscle length and load. In the guinea pig, IT is entirely suppressed by the cyclooxygenase inhibitor indomethacin. IT could be measured as the difference between resting tone before and after indomethacin addition. We examined, in electrically stimulated TSM strips (n = 9), the influence of initial muscle length (Li) on IT, the relationship between IT and the maximum extent of relaxation (Delta F1), and the influence of indomethacin on active isometric force. When Li decreased from 100 to 75% of optimal Li, there was a significant decrease in IT (from 12.0 ± 0.2 to 5.3 ± 0.1 mN; P < 0.001). Over the range of Li studied, Delta F1 underestimated the amount of IT, but there was a close linear relationship between Delta F1 and IT (r = 0.9). Compared with the basal state, indomethacin increased active isometric force (from 9.5 ± 1.0 to 19.7 ± 2.0 mN at optimal Li; P < 0.001) and induced its length dependency. In guinea pig TSM, Li was an important determinant of IT.

airway hyperreactivity; indomethacin; relaxation; mechanics


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