| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Pediatrics, 2 Medicine, 3 Pharmacology, and 4 Pathology, University of Miami School of Medicine, Miami, Florida 33136; and 5 Central Research Division, Pfizer, Inc., Groton, Connecticut 06340
Respiratory syncytial virus (RSV) is a major respiratory pathogen in infants. The first goal of this study was to determine whether the infection following endotracheal inoculation of RSV in Fischer 344 rats results in increased inflammatory responses to substance P (SP) either released by capsaicin from sensory nerves or injected into the circulation. Five days after inoculation, the extravasation of Evans blue-labeled albumin after capsaicin or SP was significantly greater in RSV-infected airways than in pathogen-free controls. The peptide-degrading activity of the regulatory enzyme neutral endopeptidase was unaffected by RSV. However, SP(NK1) receptor mRNA levels increased fivefold in RSV-infected lungs, and the density of SP binding sites in the bronchial mucosa increased threefold. These data suggest that RSV makes the airways abnormally susceptible to the proinflammatory effects of SP by upregulating SP(NK1) receptor gene expression, thereby increasing the density of these receptors on target cells. This effect may contribute to the inflammatory reaction to the virus and could be a target for the therapy of RSV disease and its sequelae.
airway inflammation; asthma; bronchiolitis; neurokinin receptors; sensory nerves
This article has been cited by other articles:
|
|
 |
|
  L. Tortorolo, A. Langer, G. Polidori, G. Vento, B. Stampachiacchere, L. Aloe, and G. Piedimonte Neurotrophin Overexpression in Lower Airways of Infants with Respiratory Syncytial Virus Infection Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 233 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Auais, B. Adkins, G. Napchan, and G. Piedimonte Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L105 - L113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hu, K. Wedde-Beer, A. Auais, M. M. Rodriguez, and G. Piedimonte Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L494 - L502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Haynes, J. Tonkin, L. J. Anderson, and R. A. Tripp Neutralizing Anti-F Glycoprotein and Anti-Substance P Antibody Treatment Effectively Reduces Infection and Inflammation Associated with Respiratory Syncytial Virus Infection J. Virol., June 14, 2002; 76(14): 6873 - 6881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Payne, C. J. Heggie, D. G. Brownstein, J. P. Stewart, and J. P. Quinn Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection J. Virol., November 1, 2001; 75(21): 10467 - 10471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. PIEDIMONTE Neural Mechanisms of Respiratory Syncytial Virus-induced Inflammation and Prevention of Respiratory Syncytial Virus Sequelae Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): S18 - 21. [Full Text] [PDF]
|
|
|
|
|
|
K. Wedde-Beer, C. Hu, M. M. Rodriguez, and G. Piedimonte Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L1143 - L1150. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
