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Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-0602
In a two-hit model of acid aspiration
lung injury, mice were subjected to nonlethal cecal ligation and
puncture (CLP). After 48 h, intratracheal (IT) acid was administered,
and mice were killed at several time points. Recruitment of neutrophils
in response to acid was documented by myeloperoxidase assay and
neutrophil counts in bronchoalveolar lavage (BAL) fluid and
peaked at 8 h post-IT injection. Albumin in BAL
fluid, an indicator of lung injury, also peaked
at 8 h. When the contributions of the two hits were compared,
neutrophil recruitment and lung injury occurred in response to acid but
were not greatly influenced by addition of another hit. Neutrophil
sequestration was preceded by elevations in KC and macrophage
inflammatory protein-2
in plasma and BAL fluid. KC levels in BAL
fluid were higher and peaked earlier than macrophage inflammatory
protein-2 levels. When KC was blocked with specific antiserum,
neutrophil recruitment was significantly reduced, whereas albumin in
BAL fluid was not affected. In conclusion, murine KC mediated
neutrophil recruitment but not lung injury in a two-hit model
of aspiration lung injury.
chemokines; KC; neutrophil
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