AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 279: L429-L438, 2000;
1040-0605/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (135)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dempsey, E. C.
Right arrow Articles by Messing, R. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dempsey, E. C.
Right arrow Articles by Messing, R. O.
Vol. 279, Issue 3, L429-L438, September 2000

EB2000 SYMPOSIUM REPORT
Protein kinase C isozymes and the regulation of diverse cell responses

Edward C. Dempsey1,2, Alexandra C. Newton3, Daria Mochly-Rosen4, Alan P. Fields5, Mary E. Reyland6, Paul A. Insel3, and Robert O. Messing7

1 Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, and 6 Department of Basic Science and Oral Research, School of Dentistry, University of Colorado Health Sciences Center, Denver 80262; 2 Denver Veterans Affairs Medical Center, Denver, Colorado 80220; 3 Department of Pharmacology, University of California, San Diego, La Jolla 92093; 4 Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford 94305; 7 Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608; and 5 Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555

Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability, contraction, migration, hypertrophy, proliferation, apoptosis, and secretion. New ideas on mechanisms that regulate PKC activity, including the identification of a novel PKC kinase, 3-phosphoinositide-dependent kinase-1 (PDK-1), that regulates phosphorylation of PKC, have been advanced. The importance of targeted translocation of PKC and isozyme-specific binding proteins (like receptors for activated C-kinase and caveolins) is well established. Phosphorylation state and localization are now thought to be key determinants of isozyme activity and specificity. New concepts on the role of individual PKC isozymes in proliferation and apoptosis are emerging. Opposing roles for selected isozymes in the same cell system have been defined. Coupling to the Wnt signaling pathway has been described. Phenotypes for PKC knockout mice have recently been reported. More specific approaches for studying PKC isozymes and their role in cell responses have been developed. Strengths and weaknesses of different experimental strategies are reviewed. Future directions for investigation are identified.

pulmonary disease; proliferation; apoptosis; 3-phosphoinositide-dependent kinase-1; receptor for activated C-kinase; transgenic mice


This article has been cited by other articles:


Home page
 Cancer Res.Home page
E. E.W. Cohen, H. Zhu, M. W. Lingen, L. E. Martin, W.-L. Kuo, E. A. Choi, M. Kocherginsky, J. S. Parker, C. H. Chung, and M. R. Rosner
A Feed-Forward Loop Involving Protein Kinase C{alpha} and MicroRNAs Regulates Tumor Cell Cycle
Cancer Res., January 1, 2009; 69(1): 65 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Villar, H. S. Quadri, I. Song, Y. Tomita, O. M. Tirado, and V. Notario
PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C{alpha}-Mediated Bcl-2 Stabilization
Cancer Res., January 1, 2009; 69(1): 102 - 110.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Armstrong, A. Pereverzev, S. J. Dixon, and S. M. Sims
Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts
J. Cell Sci., January 1, 2009; 122(1): 136 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Perry, D. O. Quissell, M. E. Reyland, and I. I. Grichtchenko
Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells
Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1385 - C1398.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. F. Steinberg
Structural Basis of Protein Kinase C Isoform Function
Physiol Rev, October 1, 2008; 88(4): 1341 - 1378.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. Davis, M. V. Westfall, D. Townsend, M. Blankinship, T. J. Herron, G. Guerrero-Serna, W. Wang, E. Devaney, and J. M. Metzger
Designing Heart Performance by Gene Transfer
Physiol Rev, October 1, 2008; 88(4): 1567 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
N. Sakai, H. Terami, S. Suzuki, M. Haga, K. Nomoto, N. Tsuchida, K.-i. Morohashi, N. Saito, M. Asada, M. Hashimoto, et al.
Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies
J. Endocrinol., September 1, 2008; 198(3): 489 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Smani, T. Patel, and V. M. Bolotina
Complex regulation of store-operated Ca2+ entry pathway by PKC-{varepsilon} in vascular SMCs
Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1499 - C1508.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. J Delvecchio and J. P Capone
Protein kinase C {alpha} modulates liver X receptor {alpha} transactivation
J. Endocrinol., April 1, 2008; 197(1): 121 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Zhiyong Zhao, Y.-K. Wu, and E. A. Reece
Demonstration of the Essential Role of Protein Kinase C Isoforms in Hyperglycemia-Induced Embryonic Malformations
Reproductive Sciences, April 1, 2008; 15(4): 349 - 356.
[Abstract] [PDF]

Home page
 Eur Respir JHome page
H. Slevogt, L. Maqami, K. Vardarowa, W. Beermann, A. C. Hocke, J. Eitel, B. Schmeck, A. Weimann, B. Opitz, S. Hippenstiel, et al.
Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms
Eur. Respir. J., April 1, 2008; 31(4): 725 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. D. Ramnath, J. Sun, S. Adhikari, L. Zhi, and M. Bhatia
Role of PKC-{delta} on substance P-induced chemokine synthesis in pancreatic acinar cells
Am J Physiol Cell Physiol, March 1, 2008; 294(3): C683 - C692.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. M. D'Souza, N. N. Petrashevskaya, W. H. Merrill, and S. A. Akhter
Inhibition of protein kinase C{alpha} improves myocardial -adrenergic receptor signaling and ventricular function in a model of myocardial preservation
J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 172 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Amos, M. Mut, C. G. diPierro, J. E. Carpenter, A. Xiao, Z. A. Kohutek, G. T. Redpath, Y. Zhao, J. Wang, M. E. Shaffrey, et al.
Protein Kinase C-{alpha} Mediated Regulation of Low-Density Lipoprotein Receptor Related Protein and Urokinase Increases Astrocytoma Invasion
Cancer Res., November 1, 2007; 67(21): 10241 - 10251.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Meier, J. Menne, J.-K. Park, and H. Haller
Nailing down PKC isoform specificity in diabetic nephropathy two's company, three's a crowd
Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2421 - 2425.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
K.-M. Bae, H. Wang, G. Jiang, M. G. Chen, L. Lu, and L. Xiao
Protein Kinase C{varepsilon} Is Overexpressed in Primary Human Non-Small Cell Lung Cancers and Functionally Required for Proliferation of Non-Small Cell Lung Cancer Cells in a p21/Cip1-Dependent Manner
Cancer Res., July 1, 2007; 67(13): 6053 - 6063.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. L. House, S. J. Melhorn, G. Newman, T. Doetschman, and J. E. J. Schultz
The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H354 - H365.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Reppel, B. K. Fleischmann, H. Reuter, P. Sasse, H. Schunkert, and J. Hescheler
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart
Cardiovasc Res, July 1, 2007; 75(1): 99 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
R. Gomel, C. Xiang, S. Finniss, H. K. Lee, W. Lu, H. Okhrimenko, and C. Brodie
The Localization of Protein Kinase C{delta} in Different Subcellular Sites Affects Its Proapoptotic and Antiapoptotic Functions and the Activation of Distinct Downstream Signaling Pathways
Mol. Cancer Res., June 1, 2007; 5(6): 627 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Clavijo, J.-L. Chen, K.-J. Kim, M. E. Reyland, and D. K. Ann
Protein kinase C{delta}-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2150 - C2160.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Zhang, A. Kanthasamy, Y. Yang, V. Anantharam, and A. Kanthasamy
Protein Kinase C{delta} Negatively Regulates Tyrosine Hydroxylase Activity and Dopamine Synthesis by Enhancing Protein Phosphatase-2A Activity in Dopaminergic Neurons
J. Neurosci., May 16, 2007; 27(20): 5349 - 5362.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Meier, J. Menne, J.-K. Park, M. Holtz, F. Gueler, T. Kirsch, M. Schiffer, M. Mengel, C. Lindschau, M. Leitges, et al.
Deletion of Protein Kinase C-{varepsilon} Signaling Pathway Induces Glomerulosclerosis and Tubulointerstitial Fibrosis In Vivo
J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1190 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Preiss, D. Namgaladze, and B. Brune
Critical role for classical PKC in activating Akt by phospholipase A2-modified LDL in monocytic cells
Cardiovasc Res, March 1, 2007; 73(4): 833 - 840.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Meier, J.-K. Park, D. Overheu, T. Kirsch, C. Lindschau, F. Gueler, M. Leitges, J. Menne, and H. Haller
Deletion of Protein Kinase C-{beta} Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model
Diabetes, February 1, 2007; 56(2): 346 - 354.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. T. Abrams, T. Lakum, K. Lin, G. M. Jones, A. T. Treweeke, M. Farahani, M. Hughes, M. Zuzel, and J. R. Slupsky
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase C{beta}II
Blood, February 1, 2007; 109(3): 1193 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J.-Y. Park, H.-W. Kang, H.-J. Moon, S.-U. Huh, S.-W. Jeong, N. M. Soldatov, and J.-H. Lee
Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density
J. Physiol., December 1, 2006; 577(2): 513 - 523.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Zhang, M. Liao, and M. L. Dufau
Phosphatidylinositol 3-Kinase/Protein Kinase C{zeta}-Induced Phosphorylation of Sp1 and p107 Repressor Release Have a Critical Role in Histone Deacetylase Inhibitor-Mediated Depression of Transcription of the Luteinizing Hormone Receptor Gene.
Mol. Cell. Biol., September 1, 2006; 26(18): 6748 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Satoh, A. S. Gukovskaya, J. R. Reeve Jr, T. Shimosegawa, and S. J. Pandol
Ethanol sensitizes NF-{kappa}B activation in pancreatic acinar cells through effects on protein kinase C-{epsilon}
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G432 - G438.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Hambleton, H. Hahn, S. T. Pleger, M. C. Kuhn, R. Klevitsky, A. N. Carr, T. F. Kimball, T. E. Hewett, G. W. Dorn II, W. J. Koch, et al.
Pharmacological- and Gene Therapy-Based Inhibition of Protein Kinase C{alpha}/{beta} Enhances Cardiac Contractility and Attenuates Heart Failure
Circulation, August 8, 2006; 114(6): 574 - 582.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
X. Lin, Y. Yu, H. Zhao, Y. Zhang, J. Manela, and D. A. Tonetti
Overexpression of PKC{alpha} is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model
Carcinogenesis, August 1, 2006; 27(8): 1538 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Le, L. Krilov, J. Meng, K. Chapin-Kennedy, S. Ceryak, and B. Bouscarel
Bile acids stimulate PKC{alpha} autophosphorylation and activation: role in the attenuation of prostaglandin E1-induced cAMP production in human dermal fibroblasts
Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G275 - G287.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Oster and M. Leitges
Protein Kinase C {alpha} but not PKC{zeta} Suppresses Intestinal Tumor Formation in ApcMin/+ Mice.
Cancer Res., July 15, 2006; 66(14): 6955 - 6963.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Mukherjee, K. A. Apple, C. E. Squires, B. S. Kaplan, J. E. McLean, S. M. Saunders, R. E. Stroud, and F. G. Spinale
Protein Kinase C Isoform Activation and Endothelin-1 Mediated Defects in Myocyte Contractility After Cardioplegic Arrest and Reperfusion
Circulation, July 4, 2006; 114(1_suppl): I-308 - I-313.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. E. W. Cohen, M. W. Lingen, B. Zhu, H. Zhu, M. W. Straza, C. Pierce, L. E. Martin, and M. R. Rosner
Protein Kinase C{zeta} Mediates Epidermal Growth Factor-Induced Growth of Head and Neck Tumor Cells by Regulating Mitogen-Activated Protein Kinase.
Cancer Res., June 15, 2006; 66(12): 6296 - 6303.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, J. Huang, N. Yang, S. Liang, A. Barchetti, A. Giannakakis, M. G. Cadungog, A. O'Brien-Jenkins, M. Massobrio, K. F. Roby, et al.
Integrative Genomic Analysis of Protein Kinase C (PKC) Family Identifies PKC{iota} as a Biomarker and Potential Oncogene in Ovarian Carcinoma.
Cancer Res., May 1, 2006; 66(9): 4627 - 4635.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Fang, Y. Huang, and Z. Zuo
Enhancement of substrate-gated Cl- currents via rat glutamate transporter EAAT4 by PMA
Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1334 - C1340.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. Warwar, S. Efendic, C.-G. Ostenson, E. P. Haber, E. Cerasi, and R. Nesher
Dynamics of Glucose-Induced Localization of PKC Isoenzymes in Pancreatic {beta}-Cells: Diabetes-Related Changes in the GK Rat
Diabetes, March 1, 2006; 55(3): 590 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Ding, C. Huang, Y. Lu, L. Bowman, V. Castranova, and V. Vallyathan
Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L291 - L297.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Hashim, G. Mulcahy, B. Bourke, and M. Clyne
Interaction of Cryptosporidium hominis and Cryptosporidium parvum with Primary Human and Bovine Intestinal Cells
Infect. Immun., January 1, 2006; 74(1): 99 - 107.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Z. Zhao and E. A. Reece
Experimental Mechanisms of Diabetic Embryopathy and Strategies for Developing Therapeutic Interventions
Reproductive Sciences, December 1, 2005; 12(8): 549 - 557.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. M. Littler, C. A. Wehling, M. J. Wick, K. A. Fagan, C. D. Cool, R. O. Messing, and E. C. Dempsey
Divergent contractile and structural responses of the murine PKC-{epsilon} null pulmonary circulation to chronic hypoxia
Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1083 - L1093.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
D. Ron and R. Jurd
The "Ups and Downs" of Signaling Cascades in Addiction
Sci. Signal., November 8, 2005; 2005(309): re14 - re14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. C. Del Castillo, M. Fedor-Chaiken, J. C. Song, V. Starlinger, J. Yoo, K. S. Matlin, and J. B. Matthews
Dynamic regulation of Na+-K+-2Cl- cotransporter surface expression by PKC-{epsilon} in Cl--secretory epithelia
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1332 - C1343.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H. Dehghani, C. Reith, and A. C Hahnel
Subcellular localization of protein kinase C {delta} and {varepsilon} affects transcriptional and post-transcriptional processes in four-cell mouse embryos
Reproduction, October 1, 2005; 130(4): 453 - 465.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Partovian, Z. Zhuang, K. Moodie, M. Lin, N. Ouchi, W. C. Sessa, K. Walsh, and M. Simons
PKC{alpha} Activates eNOS and Increases Arterial Blood Flow In Vivo
Circ. Res., September 2, 2005; 97(5): 482 - 487.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Hampson, H. Chahal, F. Khanim, R. Hayden, A. Mulder, L. K. Assi, C. M. Bunce, and J. M. Lord
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
Blood, August 15, 2005; 106(4): 1362 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Wilmanski, M. Siddiqi, E. A. Deitch, and Z. Spolarics
Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages
J. Leukoc. Biol., July 1, 2005; 78(1): 85 - 94.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. L. Galindo, A. A. Fadl, J. Sha, L. Pillai, C. Gutierrez Jr., and A. K. Chopra
Microarray and Proteomics Analyses of Human Intestinal Epithelial Cells Treated with the Aeromonas hydrophila Cytotoxic Enterotoxin
Infect. Immun., May 1, 2005; 73(5): 2628 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Seki, H. Matsubayashi, T. Amano, Y. Shirai, N. Saito, and N. Sakai
Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC
Genes Cells, March 1, 2005; 10(3): 225 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
V. Randriamboavonjy, L. Kiss, J. R. Falck, R. Busse, and I. Fleming
The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation
Cardiovasc Res, February 1, 2005; 65(2): 487 - 494.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. J Rose, B. J Michell, B. E Kemp, and M. Hargreaves
Effect of exercise on protein kinase C activity and localization in human skeletal muscle
J. Physiol., December 15, 2004; 561(3): 861 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
G. M. Fimia, C. Evangelisti, T. Alonzi, M. Romani, F. Fratini, G. Paonessa, G. Ippolito, M. Tripodi, and M. Piacentini
Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation
J. Virol., December 1, 2004; 78(23): 12809 - 12816.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Satoh, A. S. Gukovskaya, J. M. Nieto, J. H. Cheng, I. Gukovsky, J. R. Reeve Jr, T. Shimosegawa, and S. J. Pandol
PKC-{delta} and -{epsilon} regulate NF-{kappa}B activation induced by cholecystokinin and TNF-{alpha} in pancreatic acinar cells
Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G582 - G591.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Wheaton and K. Riabowol
Protein Kinase C{delta} Blocks Immediate-Early Gene Expression in Senescent Cells by Inactivating Serum Response Factor
Mol. Cell. Biol., August 15, 2004; 24(16): 7298 - 7311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-X. Wang, C. McCrudden, Y.-P. Dai, B. Horowitz, J. R. Hume, and I. A. Yamboliev
Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H533 - H544.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H.-Y. Park, H. Wu, C. E. Killoran, and B. A. Gilchrest
The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-{beta} on melanosomes
J. Cell Sci., July 15, 2004; 117(16): 3659 - 3668.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. N. Pandey, Y. Dwivedi, H. S. Rizavi, X. Ren, and R. R. Conley
Decreased Catalytic Activity and Expression of Protein Kinase C Isozymes in Teenage Suicide Victims: A Postmortem Brain Study
Arch Gen Psychiatry, July 1, 2004; 61(7): 685 - 693.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. Liu, M. L. Godwin, and G. Nowak
Protein kinase C-{alpha} inhibits the repair of oxidative phosphory