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Am J Physiol Lung Cell Mol Physiol 279: L722-L732, 2000;
1040-0605/00 $5.00
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Vol. 279, Issue 4, L722-L732, October 2000

Control of the mode of excitation-contraction coupling by Ca2+ stores in bovine trachealis muscle

Liang Tao1, Yu Huang2, and Jean-Pierre Bourreau1

1 Research Group in Mechanisms of Diseases, Department of Physiology, Faculty of Medicine, The University of Hong Kong, and 2 Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China SAR

Full muscarinic stimulation in bovine tracheal smooth muscle caused a sustained contraction and increase in intracellular Ca2+ concentration ([Ca2+]i) that was largely resistant to inhibition by nifedipine. Depletion of internal Ca2+ stores with cyclopiazonic acid resulted in an increased efficacy of nifedipine to inhibit this contraction and the associated increase in [Ca2+]i. Thus internal Ca2+ store depletion promoted electromechanical coupling between full muscarinic stimulation and muscle contraction to the detriment of pharmacomechanical coupling. A similar change in coupling mode was induced by ryanodine even when it did not significantly modify the initial transient increase in [Ca2+]i induced by this stimulation, indicating that depletion of internal stores was not necessary to induce the change in excitation-contraction coupling mode. Blockade of the Ca2+-activated K+ channel by tetraethylammonium, charybdotoxin, and iberiotoxin all induced the change in excitation-contraction coupling mode. These results suggest that in this preparation, Ca2+ released from the ryanodine-sensitive Ca2+ store, by activating Ca2+-activated K+ channels, plays a central role in determining the expression of the pharmacomechanical coupling mode between muscarinic excitation and the Ca2+ influx necessary for the maintenance of tone.

calcium release; calcium influx; potassium channels; tracheal smooth muscle


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