AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L258-L263, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blumberg, F. C.
Right arrow Articles by Pfeifer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blumberg, F. C.
Right arrow Articles by Pfeifer, M.
Vol. 280, Issue 2, L258-L263, February 2001

The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs

Friedrich C. Blumberg1, Konrad Wolf2, Peter Sandner2, Cornelia Lorenz1, Günter A. J. Riegger1, and Michael Pfeifer1

1 Department of Internal Medicine II and 2 Institute of Physiology, University of Regensburg, 93042 Regensburg, Germany

We investigated the effects of the nitric oxide (NO) donor molsidomine and the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) on pulmonary endothelin (ET)-1 gene expression and ET-1 plasma levels in chronic hypoxic rats. Two and four weeks of hypoxia (10% O2) significantly increased right ventricular systolic pressure, the medial cross-sectional vascular wall area of the pulmonary arteries, and pulmonary ET-1 mRNA expression (2-fold and 3.2-fold, respectively). ET-1 plasma levels were elevated after 4 wk of hypoxia. In rats exposed to 4 wk of hypoxia, molsidomine (15 mg · kg-1 · day-1) given either from the beginning or after 2 wk of hypoxia significantly reduced pulmonary hypertension, pulmonary vascular remodeling, pulmonary ET-1 gene expression, and ET-1 plasma levels. L-NAME administration (45 mg · kg-1 · day-1) in rats subjected to 2 wk of hypoxia did not modify these parameters. Our findings suggest that in chronic hypoxic rats, exogenously administered NO acts in part by suppressing the formation of ET-1. In contrast, inhibition of endogenous NO production exerts only minor effects on the pulmonary circulation and pulmonary ET-1 synthesis in these animals.

pulmonary hypertension; chronic hypoxia; nitric oxide


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. K. Kelly, S. Wedgwood, R. H. Steinhorn, and S. M. Black
Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L984 - L991.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. C. Blumberg, K. Wolf, M. Arzt, C. Lorenz, G. A. J. Riegger, and M. Pfeifer
Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs
J Appl Physiol, February 1, 2003; 94(2): 446 - 452.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Earley, L. D. Nelin, L. G. Chicoine, and B. R. Walker
Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide
J Appl Physiol, March 1, 2002; 92(3): 1152 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. R. Karamsetty and J. R. Klinger
NO: More Than Just a Vasodilator in Lung Transplantation
Am. J. Respir. Cell Mol. Biol., January 1, 2002; 26(1): 1 - 5.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online