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Am J Physiol Lung Cell Mol Physiol 281: L1264-L1270, 2001;
1040-0605/01 $5.00
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Vol. 281, Issue 5, L1264-L1270, November 2001

Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow

Jorge A. Gutierrez1, Andrew J. Parry2, D. Michael McMullan2, Cheryl J. Chapin1, and Jeffrey R. Fineman1,3

Departments of 1 Pediatrics and 2 Surgery and 3 Cardiovascular Research Institute, University of California, San Francisco, California 94143

Infants with increased pulmonary blood flow secondary to congenital heart disease suffer from tachypnea, dyspnea, and recurrent pulmonary infections. We have recently established a model of pulmonary hypertension secondary to increased pulmonary blood flow in lambs after in utero placement of an aortopulmonary vascular graft. The purpose of the present study was to utilize our animal model to determine the effects on the expression of surfactant proteins A (SP-A), B (SP-B), and C (SP-C). At age 4 wk, SP-A mRNA content in lambs decreased to 61.4 ± 8% of age-matched control value (n = 5; P < 0.05). In addition, SP-A protein content was decreased to 50 ± 12% of control value (n = 6; P < 0.0001). Although we did not observe statistically significant changes in SP-B mRNA content, SP-B protein was decreased to 74 ± 25% of control value (n = 4; P < 0.02). There was no difference in SP-C mRNA. These data show that in a model of congenital heart disease with pulmonary hypertension secondary to increased pulmonary blood flow, there is a decrease in SP-A gene expression as well as a decrease in SP-A and SP-B protein contents.

congenital heart disease; gene expression; overcirculation


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