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Am J Physiol Lung Cell Mol Physiol 282: L421-L430, 2002. First published November 16, 2001; doi:10.1152/ajplung.00147.2001
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Vol. 282, Issue 3, L421-L430, March 2002

SPECIAL TOPIC
Pre- and Postnatal Lung Development, Maturation, and Plasticity
Axonemal dynein expression in human fetal tracheal epithelium

Johnny L. Carson1,2,3, William Reed1,3, Thomas Lucier1, Luisa Brighton3, Todd M. Gambling1, Chien-Hui Huang1, and Albert M. Collier1,3

Departments of 1 Pediatrics and 2 Cell and Developmental Biology, and 3 The Center for Environmental Medicine and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

Ciliogenesis in human fetal airway epithelium occurs from 11 to 24 gestational weeks. Using genetic and antigenic markers specific for human axonemal dynein heavy chain 9, we characterized temporal aspects of axonemal dynein expression associated with large airway epithelial ciliogenesis during human fetal development. Late in the first trimester, an undifferentiated columnar epithelium is characteristic of the large airways, and immunocytochemical studies exhibited focal localization of axonemal dynein antigen on luminal epithelial cell borders at sites consistent with emergent ciliary beds. From 12 to 22 wk, immunocytochemical labeling of new ciliary beds was prominent, and localization within the cytoplasm of epithelial cells suggested avid synthesis of axonemal dynein in advance of ciliogenic events. Quantitative RT-PCR of tracheal RNA and in situ hybridization studies compared favorably with immunocytochemical findings with the earliest expression of axonemal dynein at 9-10 wk gestation. These studies have documented that axonemal dynein is expressed early in human fetal life during airway epithelial maturation and well before histological or ultrastructural evidence of ciliogenesis is apparent.

cilia; ciliogenesis; human fetal airway epithelium


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