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Medical Research Council Centre for Developmental Neurobiology, King's College London, London SE1 9RT, United Kingdom
Endogenous retinoids have been
implicated in alveologenesis in both the rat and the mouse, and
exogenous retinoic acid (RA) can reverse or partially reverse
experimental emphysema in adult rat and mouse models by an unknown
mechanism. In this study, we examine the cellular and molecular biology
of retinoid signaling during alveologenesis in the mouse. We describe
the temporal and spatial expression of the retinoid binding
proteins CRBP-I, CRBP-II, and CRABP-I using RT-PCR and
immunohistochemistry. We identify the retinoic acid receptor isoforms
RAR-
1, RAR-
2, RAR-4, and RAR-
2 and describe their temporal
and spatial expression using RT-PCR and in situ hybridization. We
demonstrate that both retinoid binding proteins and RAR isoforms are
temporally regulated and found within the alveolar septal regions
during alveologenesis. These data support a role of dynamic endogenous
RA signaling during alveolar formation.
lung development; alveolar regeneration; bronchopulmonary dysplasia; emphysema
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