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Am J Physiol Lung Cell Mol Physiol 282: L642-L649, 2002; doi:10.1152/ajplung.00417.2000
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Vol. 282, Issue 4, L642-L649, April 2002

SPECIAL TOPIC
Alveolar Epithelial Ion and Fluid Transport
Ca2+-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs

Andreas Norlin1 and Hans G. Folkesson2

1 Department of Animal Physiology, Lund University, SE-223 62 Lund, Sweden; and 2 Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272-0095

We investigated the importance of changes in intracellular Ca2+ concentration ([Ca2+]i) for amiloride-sensitive alveolar fluid clearance (AFC) in late-gestational guinea pigs. Fetal guinea pigs of 61, 68, and 69 days (term) gestation were investigated under normal conditions and after oxytocin-induced preterm labor. AFC or alveolar fluid secretion was measured using an impermeable tracer technique. At 61 days gestation there was net secretion of fluid into the lungs, and at birth the lungs cleared 49 ± 7% of the instilled fluid volume over 1 h. Induction of preterm labor with oxytocin induced AFC at 61 days gestation. When present, AFC was inhibited or reversed to net fluid secretion by amiloride (10-3 M). Inhibition of membrane Ca2+ channels by verapamil (10-4 M) or depletion of intracellular Ca2+ by thapsigargin (10-5 M) reduced AFC when net AFC was evident. Amiloride lacked an inhibitory effect on AFC when instilled with verapamil or thapsigargin. The results indicate that AFC via amiloride-sensitive pathways develops during late gestation, and that inducing preterm labor precociously may activate such pathways. Our results suggest that Ca2+ may act as a second messenger in mediating catecholamine-stimulated AFC.

amiloride; birth; sodium transport; oxytocin-induced preterm labor


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