AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 283: L288-L296, 2002. First published March 22, 2002; doi:10.1152/ajplung.00204.2001
1040-0605/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/L288    most recent
00204.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schultz, C. J.
Right arrow Articles by Torday, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schultz, C. J.
Right arrow Articles by Torday, J. S.
Vol. 283, Issue 2, L288-L296, August 2002

Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells

C. J. Schultz1, E. Torres2, C. Londos1, and J. S. Torday2

1 Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-2715; and 2 Departments of Pediatrics and Obstetrics and Gynecology, Harbor-UCLA Medical Center Research and Education Institute, University of California at Los Angeles, Torrance, California 90502

Adipocyte differentiation-related protein (ADrP) is an intrinsic lipid storage droplet protein that is highly expressed in lung. ADrP localizes to lipid storage droplets within lipofibroblasts, pulmonary cells characterized by high triacylglycerol, which is a precursor for surfactant phospholipid synthesis by alveolar type II epithelial (EPII) cells. The developmental pattern of ADrP mRNA and protein expression in lung tissue parallels triacylglycerol accumulation in rat lung. ADrP mRNA levels are relatively high in isolated lipofibroblasts, accounting for the high ADrP expression in lung. Isolated EPII cells, which do not store neutral lipids but derive them from lipofibroblasts, have low levels of ADrP mRNA expression. ADrP is found around lipid droplets in cultured lipofibroblasts, but not in EPII cells isolated from developing rat lung. After coculture with lipofibroblasts, EPII cells acquired ADrP, which associates with lipid droplets. Furthermore, 3H-labeled triolein in isolated ADrP-coated lipid droplets is a tenfold better substrate for surfactant phospholipid synthesis by cultured EPII cells than 3H-labeled synthetic triolein alone. Antibodies to ADrP block transfer of neutral lipid. These data suggest a role for ADrP in this novel mechanism for the transfer of lipid between lipofibroblasts and EPII cells.

lipid storage droplets; neutral lipids; fetal lung development


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
K. T. Hennrick, A. G. Keeton, S. Nanua, T. G. Kijek, A. M. Goldsmith, U. S. Sajjan, J. K. Bentley, V. N. Lama, B. B. Moore, R. E. Schumacher, et al.
Lung Cells from Neonates Show a Mesenchymal Stem Cell Phenotype
Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1158 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. S. Torday and V. K. Rehan
The evolutionary continuum from lung development to homeostasis and repair
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L608 - L611.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. L. Magra, P. S. Mertz, J. S. Torday, and C. Londos
Role of adipose differentiation-related protein in lung surfactant production: a reassessment
J. Lipid Res., November 1, 2006; 47(11): 2367 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Masuda, H. Itabe, M. Odaki, K. Hama, Y. Fujimoto, M. Mori, N. Sasabe, J. Aoki, H. Arai, and T. Takano
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells
J. Lipid Res., January 1, 2006; 47(1): 87 - 98.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yamaguchi, N. Omatsu, S. Matsushita, and T. Osumi
CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets: POSSIBLE INVOLVEMENT OF CGI-58 MISLOCALIZATION IN CHANARIN-DORFMAN SYNDROME
J. Biol. Chem., July 16, 2004; 279(29): 30490 - 30497.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. S. Torday and V. K. Rehan
Deconvoluting Lung Evolution Using Functional/Comparative Genomics
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 8 - 12.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.S. Torday and V.K. Rehan
Does "A" stand for alveolization?
Eur. Respir. J., January 1, 2004; 23(1): 3 - 4.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Miura, J.-W. Gan, J. Brzostowski, M. J. Parisi, C. J. Schultz, C. Londos, B. Oliver, and A. R. Kimmel
Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals, Drosophila, and Dictyostelium
J. Biol. Chem., August 23, 2002; 277(35): 32253 - 32257.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online