AJP - Lung AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 284: L260-L269, 2003. First published September 6, 2002; doi:10.1152/ajplung.00226.2002
1040-0605/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/L260    most recent
00226.2002v2
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vargaftig, B. B.
Right arrow Articles by Singer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vargaftig, B. B.
Right arrow Articles by Singer, M.
Vol. 284, Issue 2, L260-L269, February 2003

Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs

B. Boris Vargaftig and Monique Singer

Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur-Institut National de la Santé et de la Recherche Médicale U485, Institut Pasteur, 75015 Paris, France

In mice, intratracheal challenges with antigen (ovalbumin) or recombinant murine interleukin-13 (IL-13) induce lung inflammation, bronchial hyperreactivity (BHR), and mucus accumulation as independent events (Singer M, Lefort J, and Vargaftig BB. Am J Respir Cell Mol Biol 26: 74-84, 2002), largely mediated by leukotrienes (LT). We previously showed that LTC4 was released 15 min after ovalbumin, and we show that it induces the expression of monocyte chemoattractant proteins 1 and 5 and KC in the lungs, as well as IL-13 mRNA. Instilled intratracheally, these chemokines induced BHR and mucus accumulation, which were inhibited by the 5-lipoxygenase inhibitor zileuton and by the cysteinyl-LT receptor antagonist MK-571, suggesting mediation by cysteinyl-LT. Because these chemokines also induced release of LT into the bronchoalveolar lavage fluid and IL-13 into the lungs, we hypothesize that LT- and chemokine-based loops for positive-feedback regulations cooperate to maintain and amplify BHR and lung mucus accumulation after allergic challenge and in situations where IL-13, LT, or chemokines are generated.

inflammation; asthma; MUC; leukotriene; cytokine/chemokine; bronchial hyperreactivity


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Moynihan, B. Tolloczko, M.-C. Michoud, M. Tamaoka, P. Ferraro, and J. G. Martin
MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L171 - L177.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Inoue, H. Takano, K. Hiyoshi, T. Ichinose, K. Sadakane, R. Yanagisawa, S. Tomura, and Y. Kumagai
Naphthoquinone enhances antigen-related airway inflammation in mice
Eur. Respir. J., February 1, 2007; 29(2): 259 - 267.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. S. Wagers, H. C. Haverkamp, J. H. T. Bates, R. J. Norton, J. A. Thompson-Figueroa, M. J. Sullivan, and C. G. Irvin
Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms
J Appl Physiol, January 1, 2007; 102(1): 221 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. Thai, Y. Chen, G. Dolganov, and R. Wu
Differential Regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 Expression in Airway Epithelium
Am. J. Respir. Cell Mol. Biol., December 1, 2005; 33(6): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Noguchi, E. Kuroda, and U. Yamashita
Strain difference of murine bone marrow-derived mast cell functions
J. Leukoc. Biol., September 1, 2005; 78(3): 605 - 611.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. Yang, L. Li, A. Volk, E. Emmell, T. Petley, J. Giles-Komar, P. Rafferty, M. Lakshminarayanan, D. E. Griswold, P. J. Bugelski, et al.
Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice
J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 8 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. B. Vargaftig and M. Singer
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L808 - L818.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. B. Vargaftig and M. Singer
Leukotrienes Mediate Murine Bronchopulmonary Hyperreactivity, Inflammation, and Part of Mucosal Metaplasia and Tissue Injury Induced by Recombinant Murine Interleukin-13
Am. J. Respir. Cell Mol. Biol., April 1, 2003; 28(4): 410 - 419.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online