| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology, University of Minnesota, St. Paul, Minnesota 55108
Electrolyte transport across the
adult alveolar epithelium plays an important role in maintaining a thin
fluid layer along the apical surface of the alveolus that facilitates
gas exchange across the epithelium. Most of the work published on the
transport properties of alveolar epithelial cells has focused on the
mechanisms and regulation of Na+ transport and, in
particular, the role of amiloride-sensitive Na+ channels in
the apical membrane and the Na+-K+-ATPase
located in the basolateral membrane. Less is known about the identity
and role of Cl
and K+ channels in alveolar
epithelial cells, but studies are revealing important functions for
these channels in regulation of alveolar fluid volume and ionic
composition. The purpose of this review is to examine previous work
published on Cl and K+ channels in alveolar
epithelial cells and to discuss the conclusions and speculations
regarding their role in alveolar cell transport function.
alveolar fluid clearance; Cl absorption; K+ secretion; epithelial ion transport
This article has been cited by other articles:
|
|
 |
|
  N. T. N. Trinh, A. Prive, E. Maille, J. Noel, and E. Brochiero EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L866 - L880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dagenais, R. Frechette, M.-E. Clermont, C. Masse, A. Prive, E. Brochiero, and Y. Berthiaume Dexamethasone inhibits the action of TNF on ENaC expression and activity Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1220 - L1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leroy, A. Prive, J.-C. Bourret, Y. Berthiaume, P. Ferraro, and E. Brochiero Regulation of ENaC and CFTR expression with K+ channel modulators and effect on fluid absorption across alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1207 - L1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ghiaroni, H. Fuwa, M. Inoue, M. Sasaki, K. Miyazaki, M. Hirama, T. Yasumoto, G. P. Rossini, G. Scalera, and A. Bigiani Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells Chem Senses, September 1, 2006; 31(7): 673 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mair, M. Frick, C. Bertocchi, T. Haller, A. Amberger, H. Weiss, R. Margreiter, W. Streif, and P. Dietl Inhibition by cytoplasmic nucleotides of a new cation channel in freshly isolated human and rat type II pneumocytes Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1284 - L1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kemp and K.-J. Kim Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L460 - L464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Birnbaum, A. W. Varga, L.-L. Yuan, A. E. Anderson, J. D. Sweatt, and L. A. Schrader Structure and Function of Kv4-Family Transient Potassium Channels Physiol Rev, July 1, 2004; 84(3): 803 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Fang, Y. Song, R. Zemans, J. Hirsch, and M. A. Matthay Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L104 - L110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leroy, A. Dagenais, Y. Berthiaume, and E. Brochiero Molecular identity and function in transepithelial transport of KATP channels in alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1027 - L1037. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
