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Am J Physiol Lung Cell Mol Physiol 285: L269-L280, 2003; doi:10.1152/ajplung.00424.2002
1040-0605/03 $5.00
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INVITED REVIEW

Multimodal optical imaging

Cindy Lawler,1 William A. Suk,1 Bruce R. Pitt,2 Claudette M. St. Croix,2 and Simon C. Watkins3

1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709;2Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh 15260; and 3Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

The recent resurgence of interest in the use of intravital microscopy in lung research is a manifestation of extraordinary progress in visual imaging and optical microscopy. This review evaluates the tools and instrumentation available for a number of imaging modalities, with particular attention to recent technological advances, and addresses recent progress in use of optical imaging techniques in basic pulmonary research.1 Limitations of existing methods and anticipated future developments are also identified. Although there have also been major advances made in the use of magnetic resonance imaging, positron emission tomography, and X-ray and computed tomography to image intact lungs and while these technologies have been instrumental in advancing the diagnosis and treatment of patients, the purpose of this review is to outline developing optical methods that can be evaluated for use in basic research in pulmonary biology.

fluorescent probes; green fluorescent protein; fluorescence resonance energy transfer; electron paramagnetic resonance; electron microscopy


Address for reprint requests and other correspondence: C. M. St. Croix, Dept. of Environmental and Occupational Health, Univ. of Pittsburgh Graduate School of Public Health, 3344 Forbes Ave., Pittsburgh, PA 15260 (E-mail: cls13{at}pitt.edu).






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