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Am J Physiol Lung Cell Mol Physiol 289: L153-L158, 2005. First published March 25, 2005; doi:10.1152/ajplung.00222.2004
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Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways

Christian Peiser,1 Marcello Trevisani,2 David A. Groneberg,1 Q. Thai Dinh,1 Doerthe Lencer,1 Silvia Amadesi,2 Barbara Maggiore,2 Selena Harrison,2 Pierangelo Geppetti,2 and Axel Fischer1

1Department of Pediatric Pneumology and Immunology, Charité - Virchow Campus, Berlin, Germany; and 2Department of Experimental and Clinical Medicine, Pharmacology Unit, University of Ferrara, Italy

Submitted 11 June 2004 ; accepted in final form 18 March 2005

Agonists of the dopamine receptors have been demonstrated to have bronchodilatory properties in pathologically constricted airways. The mechanism by which these agonists induce bronchodilatation is thought to involve airway sensory nerves. In this study, the expression and function of dopamine D2 receptor were examined in sensory ganglia supplying the airways. Neuronal dopamine D2 receptor mRNA expression was demonstrated by single-cell RT-PCR following laser-assisted microdissection. The projection of the neurons to the airways was confirmed by retrograde neuronal labeling. In functional studies, dopamine D2 receptor agonists (AR-C65116AB and ropinirole) inhibited intraneuronal calcium mobilization in rat capsaicin-sensitive primary sensory neurons and capsaicin-induced plasma extravasation in the rat trachea. Our results provide support to the hypothesis that dopamine D2 receptor activation inhibits neurogenic inflammation and proinflammatory reflex responses.

D2 dopamine receptor; jugular-nodose ganglion; dorsal root ganglion; rat


Address for reprint requests and other correspondence: C. Peiser, Charité- Virchow Campus, Dept. of Pediatrics, Biomedical Research Center, Augustenburger Platz 1, 13353 Berlin, Germany (E-mail: christian.peiser{at}charite.de)






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