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Am J Physiol Lung Cell Mol Physiol 289: L685-L695, 2005; doi:10.1152/ajplung.00247.2005
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INVITED REVIEW

Mechanisms of pulmonary edema clearance

Gökhan M. Mutlu and Jacob I. Sznajder

Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois

The mechanisms of pulmonary edema resolution are different from those regulating edema formation. Absorption of excess alveolar fluid is an active process that involves vectorial transport of Na+ out of alveolar air spaces with water following the Na+ osmotic gradient. Active Na+ transport across the alveolar epithelium is regulated via apical Na+ and chloride channels and basolateral Na-K-ATPase in normal and injured lungs. During lung injury, mechanisms regulating alveolar fluid reabsorption are inhibited by yet unclear pathways and can be upregulated by pharmacological means. Better understanding of the mechanisms that regulate edema clearance may lead to therapeutic interventions to improve the ability of lungs to clear fluid, which is of clinical significance.

acute lung injury; acute respiratory distress syndrome; alveolar epithelium; alveoli lung


Address for reprint requests and other correspondence: J. I. Sznajder, Pulmonary and Critical Care Medicine, Northwestern Univ. Medical School, 240 E. Huron, McGaw 2300, Chicago, IL 60611 (e-mail: j-sznajder{at}northwestern.edu)




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