HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 291/6/L1113    most recent 00266.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Garcia, J. G. N. Articles by Moreno Vinasco, L. Search for Related Content PubMed PubMed Citation Articles by Garcia, J. G. N. Articles by Moreno Vinasco, L.

EB2006 COMROE LECTURE

Genomic insights into acute inflammatory lung injury

Pulmonary and Critical Care Medicine, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois

ABSTRACT

Acute lung injury (ALI) is a devastating syndrome (usually associated with sepsis) that represents a major healthcare burden in the United States. We have focused our studies on unraveling the genetic underpinnings of this syndrome utilizing a candidate gene approach to identify novel genes for ALI susceptibility. Two novel genes identified by this approach include pre-B cell colony-enhancing factor (PBEF) and the gene for myosin light chain kinase (MLCK). PBEF protein levels were elevated in human bronchoalveolar lavage and serum samples from patients with ALI, and DNA sequencing identified two single nucleotide polymorphisms in the PBEF promoter (T-1001G, C-1543T) that were overrepresented in patients with sepsis-induced ALI. More recently, we found MLCK single polymorphisms and haplotypes to be associated with human ALI with unique variants observed in African-Americans with ALI. Thus genomic and genetic approaches represent powerful strategies in the identification of novel candidate genes and potential targets for ALI therapies.

acute respiratory distress syndrome; mechanical ventilation; single nucleotide polymorphisms; haplotype

This article has been cited by other articles:

				S.-B. Hong, Y. Huang, L. Moreno-Vinasco, S. Sammani, J. Moitra, J. W. Barnard, S.-F. Ma, T. Mirzapoiazova, C. Evenoski, R. R. Reeves, et al. Essential Role of Pre-B-Cell Colony Enhancing Factor in Ventilator-induced Lung Injury Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 605 - 617. [Abstract] [Full Text] [PDF]

				T. Luk, Z. Malam, and J. C. Marshall Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity J. Leukoc. Biol., April 1, 2008; 83(4): 804 - 816. [Abstract] [Full Text] [PDF]

				S. A. Nonas, L. M. Vinasco, S. F. Ma, J. R. Jacobson, A. A. Desai, S. M. Dudek, C. Flores, P. M. Hassoun, L. Sam, S. Q. Ye, et al. Use of consomic rats for genomic insights into ventilator-associated lung injury Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L292 - L302. [Abstract] [Full Text] [PDF]