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This Article Full Text Full Text (PDF) All Versions of this Article: 293/3/L517    most recent 00202.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chatterjee, S. Articles by Bhattacharya, J. Search for Related Content PubMed PubMed Citation Articles by Chatterjee, S. Articles by Bhattacharya, J.

EB2007 FEATURED TOPIC

Endothelial and epithelial signaling in the lung

¹Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and ²Department of Medicine and Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, St. Luke's-Roosevelt Hospital Center, New York, New York

ABSTRACT

In recent years, pulmonary research has focused increasingly on the understanding of proinflammatory endothelial and epithelial signaling pathways underlying lung injury that is well known to be associated with high morbidity and mortality. Although traditionally considered separately, current research shows considerable convergence in epithelial and endothelial signaling mechanisms. This was well emphasized in the featured topic session held during the Experimental Biology 2007 Meeting in Washington, D.C., that addressed the complex interdependence between signaling pathways in the two cellular phenotypes. Several perspectives on endothelial and epithelial signaling, as well as their contributions to pulmonary inflammation and damage, as presented and discussed in the session are summarized here.