AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 267: L223-L241, 1994;
1040-0605/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lum, H.
Right arrow Articles by Malik, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lum, H.
Right arrow Articles by Malik, A. B.

AJP - Lung Cellular and Molecular Physiology, Vol 267, Issue 3 223-L241, Copyright © 1994 by American Physiological Society

ARTICLES

Regulation of vascular endothelial barrier function

H. Lum and A. B. Malik
Department of Pharmacology, Rush Medical College/Rush-Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.

The increase in endothelial permeability in response to inflammatory mediators such as alpha-thrombin and histamine is accompanied by cell rounding and interendothelial gap formation, implicating that the predominant transport pathway is a diffusive one [i.e., via cellular junctions (paracellular transport)]. However, the possible contribution by vesicle-mediated transport (i.e., via albumin binding protein gp60) to the overall permeability increase needs investigation. Regulation of paracellular transport in endothelial cells is associated with modulation of actin-based systems which anchor the cell to its neighbor or extracellular matrix, thus maintaining endothelial integrity. At the cell-cell junctions, actin is linked indirectly to the plasma membrane by linking proteins (e.g., vinculin, catenins, alpha-actinin) to cadherins, which function in homophilic intercellular adhesion. Cadherins may also play a role in regulating the formation of tight junctions, which also may be associated with actin. At endothelial focal contacts, the transmembrane receptors (integrins) for matrix proteins are linked to actin via linking proteins (i.e., vinculin, talin, alpha-actinin). In response to inflammatory mediators, second messengers signal two regulatory pathways which modulate the actin-based systems, which may lead to impairment of the endothelial barrier integrity. One pathway is based on protein kinase C (PKC) isozyme-specific phosphorylation of linking proteins at the cell-cell and cell-matrix junctions. The increased phosphorylation is associated with actin reorganization, cell rounding, and increased paracellular transport. The other is the activation of myosin light-chain kinase, (MLCK), which causes an actin-myosin-based contraction that may lead to a centripetal retraction of endothelial cells. Current research is in the identification of protein substrates of PKC isozymes, the specific role of their phosphorylation in barrier function, and determining the precise role of MLCK in modulation of endothelial barrier function.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Bastarache, L. Wang, Z. Wang, K. H. Albertine, M. A. Matthay, and L. B. Ware
Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L874 - L881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. H. Adamson, J. C. Ly, R. K. Sarai, J. F. Lenz, A. Altangerel, D. Drenckhahn, and F. E. Curry
Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1188 - H1196.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Itagaki, J. K. Yun, J. A. Hengst, A. Yatani, C. J. Hauser, Z. Spolarics, and E. A. Deitch
Sphingosine 1-Phosphate Has Dual Functions in the Regulation of Endothelial Cell Permeability and Ca2+ Metabolism
J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 186 - 191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Zhang, H. Dong, L. J. Rubin, and J. X.-J. Yuan
Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2297 - C2305.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Okutani, M. Lodyga, B. Han, and M. Liu
Src protein tyrosine kinase family and acute inflammatory responses
Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L129 - L141.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Mehta and A. B. Malik
Signaling Mechanisms Regulating Endothelial Permeability
Physiol Rev, January 1, 2006; 86(1): 279 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. S. An, C. M. Pennella, A. Gonnabathula, J. Chen, N. Wang, M. Gaestel, P. M. Hassoun, J. J. Fredberg, and U. S. Kayyali
Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways
Am J Physiol Cell Physiol, September 1, 2005; 289(3): C521 - C530.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta
Lysophosphatidylcholine: an enigmatic lysolipid
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L174 - L175.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta, J. Bhattacharya, M. A. Matthay, and A. B. Malik
Integrated control of lung fluid balance
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1081 - L1090.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. C. Paria, S. M. Vogel, G. U. Ahmmed, S. Alamgir, J. Shroff, A. B. Malik, and C. Tiruppathi
Tumor necrosis factor-{alpha}-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1303 - L1313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta
p120: the guardian of endothelial junctional integrity
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1140 - L1142.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. Klingenberg, D. Gunduz, F. Hartel, K. Bindewald, M. Schafer, H. M. Piper, and T. Noll
MEK/MAPK as a signaling element in ATP control of endothelial myosin light chain
Am J Physiol Cell Physiol, April 1, 2004; 286(4): C807 - C812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y.-S. Nan, G.-G. Feng, Y. Hotta, K. Nishiwaki, Y. Shimada, A. Ishikawa, N. Kurimoto, T. Shigei, and N. Ishikawa
Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1027 - H1033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. H. Tinsley, N. R. Teasdale, and S. Y. Yuan
Involvement of PKC{delta} and PKD in pulmonary microvascular endothelial cell hyperpermeability
Am J Physiol Cell Physiol, January 1, 2004; 286(1): C105 - C111.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. V. Usatyuk, V. P. Fomin, S. Shi, J. G. N. Garcia, K. Schaphorst, and V. Natarajan
Role of Ca2+ in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function
Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L1006 - L1017.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Konstantoulaki, P. Kouklis, and A. B. Malik
Protein kinase C modifications of VE-cadherin, p120, and {beta}-catenin contribute to endothelial barrier dysregulation induced by thrombin
Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L434 - L442.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Qiao, F. Huang, and H. Lum
PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction
Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L972 - L980.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Siflinger-Birnboim and A. Johnson
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L435 - L451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. H. Tinsley, E. E. Ustinova, W. Xu, and S. Y. Yuan
Src-dependent, neutrophil-mediated vascular hyperpermeability and beta -catenin modification
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1745 - C1751.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Tiruppathi, M. Freichel, S. M. Vogel, B. C. Paria, D. Mehta, V. Flockerzi, and A. B. Malik
Impairment of Store-Operated Ca2+ Entry in TRPC4-/- Mice Interferes With Increase in Lung Microvascular Permeability
Circ. Res., July 12, 2002; 91(1): 70 - 76.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. G. N. GARCIA, P. WANG, K. L. SCHAPHORST, P. M. BECKER, T. BORBIEV, F. LIU, A. BIRUKOVA, K. JACOBS, N. BOGATCHEVA, and A. D. VERIN
Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability
FASEB J, July 1, 2002; 16(9): 1064 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Sakurai, T. Sakurada, Y. Ochiai, J. Yamakami, and Y. Tanaka
Stereoselective transport of histidine in rat lung microvascular endothelial cells
Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1192 - L1197.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. L. Goldberg, D. E. MacNaughton, R. T. Clements, F. L. Minnear, and P. A. Vincent
p38 MAPK activation by TGF-beta 1 increases MLC phosphorylation and endothelial monolayer permeability
Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L146 - L154.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Bardin, F. Anfosso, J.-M. Masse, E. Cramer, F. Sabatier, A. L. Bivic, J. Sampol, and F. Dignat-George
Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion
Blood, December 15, 2001; 98(13): 3677 - 3684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. G. Kevil, N. Okayama, and J. S. Alexander
H2O2-mediated permeability II: importance of tyrosine phosphatase and kinase activity
Am J Physiol Cell Physiol, December 1, 2001; 281(6): C1940 - C1947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Wang, A. D. Verin, A. Birukova, L. I. Gilbert-McClain, K. Jacobs, and J. G. N. Garcia
Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation
Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1472 - L1483.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. M. Vogel, R. D. Minshall, M. Pilipovic', C. Tiruppathi, and A. B. Malik
Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein
Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1512 - L1522.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Tiruppathi, T. Naqvi, R. Sandoval, D. Mehta, and A. B. Malik
Synergistic effects of tumor necrosis factor-{alpha} and thrombin in increasing endothelial permeability
Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L958 - L968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta
Serine/threonine phosphatase 2B regulates protein kinase C-{alpha} activity and endothelial barrier function
Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L544 - L545.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. D. Verin, A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J. G. N. Garcia
Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation
Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L565 - L574.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Patterson, G. A. Stouffer, N. Madamanchi, and M. S. Runge
New Tricks for Old Dogs : Nonthrombotic Effects of Thrombin in Vessel Wall Biology
Circ. Res., May 25, 2001; 88(10): 987 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Lum and K. A. Roebuck
Oxidant stress and endothelial cell dysfunction
Am J Physiol Cell Physiol, April 1, 2001; 280(4): C719 - C741.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Sandoval, A. B. Malik, T. Naqvi, D. Mehta, and C. Tiruppathi
Requirement for Ca2+ signaling in the mechanism of thrombin-induced increase in endothelial permeability
Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L239 - L247.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. M. VOGEL, X. GAO, D. MEHTA, R. D. YE, T. A. JOHN, P. ANDRADE-GORDON, C. TIRUPPATHI, and A. B. MALIK
Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice
Physiol Genomics, December 18, 2000; 4(2): 137 - 145.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
J. M. MULLIN, K. V. LAUGHLIN, N. GINANNI, C. W. MARANO, H. M. CLARKE, and A. PERALTA SOLER
Increased Tight Junction Permeability Can Result from Protein Kinase C Activation/Translocation and Act as a Tumor Promotional Event in Epithelial Cancers
Ann. N.Y. Acad. Sci., December 1, 2000; 915(1): 231 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Gao, P. Kouklis, N. Xu, R. D. Minshall, R. Sandoval, S. M. Vogel, and A. B. Malik
Reversibility of increased microvessel permeability in response to VE-cadherin disassembly
Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1218 - L1225.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. T. Rizzo, E. Nguyen, M. Aldo-Benson, and G. Lambeau
Secreted phospholipase A2 induces vascular endothelial cell migration
Blood, December 1, 2000; 96(12): 3809 - 3815.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Norwood, T. M. Moore, D. A. Dean, R. Bhattacharjee, M. Li, and T. Stevens
Store-operated calcium entry and increased endothelial cell permeability
Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L815 - L824.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Narravula, P. F. Lennon, B. U. Mueller, and S. P. Colgan
Regulation of Endothelial CD73 by Adenosine: Paracrine Pathway for Enhanced Endothelial Barrier Function
J. Immunol., November 1, 2000; 165(9): 5262 - 5268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. M. Moore, N. R. Norwood, J. R. Creighton, P. Babal, G. H. Brough, D. M. Shasby, and T. Stevens
Receptor-dependent activation of store-operated calcium entry increases endothelial cell permeability
Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L691 - L698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Stevens, J. G. N. Garcia, D. M. Shasby, J. Bhattacharya, and A. B. Malik
Mechanisms regulating endothelial cell barrier function
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L419 - L422.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Johnson
The conundrum of oxidant-induced barrier dysfunction
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L439 - L440.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Shi, J. G. N. Garcia, S. Roy, N. L. Parinandi, and V. Natarajan
Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L441 - L451.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Y. Yuan, E. E. Ustinova, M. H. Wu, J. H. Tinsley, W. Xu, F. L. Korompai, and A. C. Taulman
Protein Kinase C Activation Contributes to Microvascular Barrier Dysfunction in the Heart at Early Stages of Diabetes
Circ. Res., September 1, 2000; 87(5): 412 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. D. Verin, F. Liu, N. Bogatcheva, T. Borbiev, M. B. Hershenson, P. Wang, and J. G. N. Garcia
Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction
Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L360 - L370.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Tiruppathi, W. Yan, R. Sandoval, T. Naqvi, A. N. Pronin, J. L. Benovic, and A. B. Malik
G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells
PNAS, June 20, 2000; 97(13): 7440 - 7445.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N. Gautam, H. Herwald, P. Hedqvist, and L. Lindbom
Signaling via {beta}2 Integrins Triggers Neutrophil-dependent Alteration in Endothelial Barrier Function
J. Exp. Med., May 30, 2000; 191(11): 1829 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. C. Drummond, O. Meyer, K. Hong, D. B. Kirpotin, and D. Papahadjopoulos
Optimizing Liposomes for Delivery of Chemotherapeutic Agents to Solid Tumors
Pharmacol. Rev., December 1, 1999; 51(4): 691 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. H. Park, N. Okayama, D. Gute, A. Krsmanovic, H. Battarbee, and J. S. Alexander
Hypoxia/aglycemia increases endothelial permeability: role of second messengers and cytoskeleton
Am J Physiol Cell Physiol, December 1, 1999; 277(6): C1066 - C1074.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. Andriopoulou, P. Navarro, A. Zanetti, M. G. Lampugnani, and E. Dejana
Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions
Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2286 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. R. Coughlin
How the protease thrombin talks to cells
PNAS, September 28, 1999; 96(20): 11023 - 11027.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Corada, M. Mariotti, G. Thurston, K. Smith, R. Kunkel, M. Brockhaus, M. G. Lampugnani, I. Martin-Padura, A. Stoppacciaro, L. Ruco, et al.
Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
PNAS, August 17, 1999; 96(17): 9815 - 9820.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. C. Michel and F. E. Curry
Microvascular Permeability
Physiol Rev, July 1, 1999; 79(3): 703 - 761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Stevens, J. Creighton, and W. J. Thompson
Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function
Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L119 - L126.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Vouret-Craviari, D. Grall, G. Flatau, J. Pouyssegur, P. Boquet, and E. Van Obberghen-Schilling
Effects of Cytotoxic Necrotizing Factor 1 and Lethal Toxin on Actin Cytoskeleton and VE-Cadherin Localization in Human Endothelial Cell Monolayers
Infect. Immun., June 1, 1999; 67(6): 3002 - 3008.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Knapp, P. Bokník, I. Lüss, S. Huke, B. Linck, H. Lüss, F. U. Müller, T. Müller, P. Nacke, T. Noll, et al.
The Protein Phosphatase Inhibitor Cantharidin Alters Vascular Endothelial Cell Permeability
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1480 - 1486.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. G. N. Garcia, A. D. Verin, K. Schaphorst, R. Siddiqui, C. E. Patterson, C. Csortos, and V. Natarajan
Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60src
Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L989 - L998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Hurst IV, P. L. Goldberg, F. L. Minnear, R. L. Heimark, and P. A. Vincent
Rearrangement of adherens junctions by transforming growth factor-beta 1: role of contraction
Am J Physiol Lung Cell Mol Physiol, April 1, 1999; 276(4): L582 - L595.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. m. Wu, Y. Yuan, D. C. Zawieja, J. Tinsley, and H. J. Granger
Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability
Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H535 - H542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page