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Am J Physiol Lung Cell Mol Physiol 276: L1-L8, 1999;
1040-0605/99 $5.00
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Vol. 276, Issue 1, L1-L8, January 1999

Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation

Edward Abraham, Debra J. Kaneko, and Robert Shenkar

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262

Endotoxemia produces elevations in catecholamine levels in the pulmonary and systemic circulation as well as rapid increases in neutrophil number and proinflammatory cytokine expression in the lungs. In the present experiments, we examined the effects of endogenous and exogenous adrenergic stimulation on endotoxin-induced lung neutrophil accumulation and activation. Levels of interleukin (IL)-1beta , tumor necrosis factor (TNF)-alpha , and macrophage inflammatory protein (MIP)-2 mRNAs were increased in lung neutrophils from endotoxemic mice compared with those present in lung neutrophils from control mice or in peripheral blood neutrophils from endotoxemic or control mice. Treatment with the beta -adrenergic antagonist propranolol before endotoxin administration did not affect trafficking of neutrophils to the lungs or the expression of IL-1beta , TNF-alpha , or MIP-2 by lung neutrophils. Administration of the alpha -adrenergic antagonist phentolamine before endotoxemia did not alter lung neutrophil accumulation as measured by myeloperoxidase (MPO) levels but did result in significant increases in IL-1beta , TNF-alpha , and MIP-2 mRNA expression by lung neutrophils compared with endotoxemia alone. Administration of the alpha 1-adrenergic agonist phenylephrine before endotoxin did not affect trafficking of neutrophils to the lungs but was associated with significantly increased expression of TNF-alpha and MIP-2 mRNAs by lung neutrophils compared with that found after endotoxin alone. In contrast, treatment with the alpha 2-adrenergic agonist UK-14304 prevented endotoxin-induced increases in lung MPO and lung neutrophil cytokine mRNA levels. The suppressive effects of UK-14304 on endotoxin-induced increases in lung MPO were not affected by administration of the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester. These data demonstrate that the initial accumulation and activation of neutrophils in the lungs after endotoxemia can be significantly diminished by alpha 2-adrenergic stimulation. Therapy with alpha 2-adrenergic agents may have a role in modulating inflammatory pulmonary processes associated with sepsis-induced acute lung injury.

lipopolysaccharide; alpha -adrenergic; beta -adrenergic; acute lung injury; propranolol; phentolamine; UK-14304; phenylephrine; nitric oxide


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