INVITED REVIEW:

Richard M. Effros, Prapaporn Pornsuriyasak, Janos Porszasz, and Richard Casaburi

Indicator dilution measurements of extravascular lung water: basic assumptions and observations
Am J Physiol Lung Cell Mol Physiol 294: L1023-L1031, 2008. First published March 21, 2008; doi:10.1152/ajplung.00533.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

EDITORIAL FOCUS:

Michael A. Matthay

Measurement of extravascular lung water in patients with pulmonary edema
Am J Physiol Lung Cell Mol Physiol 294: L1021-L1022, 2008. First published April 25, 2008; doi:10.1152/ajplung.90279.2008 [Full Text] [PDF]  

Susan E. Wert

Does adiponectin play a role in pulmonary emphysema?
Am J Physiol Lung Cell Mol Physiol 294: L1032-L1034, 2008. First published April 18, 2008; doi:10.1152/ajplung.90273.2008 [Full Text] [PDF]  

R. Summer, F. F. Little, N. Ouchi, Y. Takemura, T. Aprahamian, D. Dwyer, K. Fitzsimmons, B. Suki, H. Parameswaran, A. Fine, and K. Walsh

Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice
Am J Physiol Lung Cell Mol Physiol 294: L1035-L1042, 2008. First published March 7, 2008; doi:10.1152/ajplung.00397.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

ARTICLES:

Wolfram Burkhardt, Petra Koehne, Heide Wissel, Susanne Graf, Hans Proquitté, Roland R. Wauer, and Mario Rüdiger

Intratracheal perfluorocarbons diminish LPS-induced increase in systemic TNF-
Am J Physiol Lung Cell Mol Physiol 294: L1043-L1048, 2008. First published March 21, 2008; doi:10.1152/ajplung.00125.2007 [Abstract] [Full Text] [PDF]  

K. L. Bailey, J. A. Poole, T. L. Mathisen, T. A. Wyatt, S. G. Von Essen, and D. J. Romberger

Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium
Am J Physiol Lung Cell Mol Physiol 294: L1049-L1054, 2008. First published March 21, 2008; doi:10.1152/ajplung.00526.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Aihua Hu, Gustavo Nino, Judith S. Grunstein, Sumbul Fatma, and Michael M. Grunstein

Prolonged heterologous β2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction
Am J Physiol Lung Cell Mol Physiol 294: L1055-L1067, 2008. First published March 21, 2008; doi:10.1152/ajplung.00021.2008 [Abstract] [Full Text] [PDF]  

Jonathan L. Koff, Matt X. G. Shao, Iris F. Ueki, and Jay A. Nadel

Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
Am J Physiol Lung Cell Mol Physiol 294: L1068-L1075, 2008. First published March 28, 2008; doi:10.1152/ajplung.00025.2008 [Abstract] [Full Text] [PDF]  

Catherine Le Quément, Isabelle Guénon, Jean-Yves Gillon, Vincent Lagente, and Elisabeth Boichot

MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells
Am J Physiol Lung Cell Mol Physiol 294: L1076-L1084, 2008. First published April 4, 2008; doi:10.1152/ajplung.00489.2007 [Abstract] [Full Text] [PDF]  

Teruaki Nishiuma, Yoshihiro Nishimura, Taro Okada, Emi Kuramoto, Yoshikazu Kotani, Saleem Jahangeer, and Shun-ichi Nakamura

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model
Am J Physiol Lung Cell Mol Physiol 294: L1085-L1093, 2008. First published March 21, 2008; doi:10.1152/ajplung.00445.2007 [Abstract] [Full Text] [PDF]  

Paul R. Reynolds, Stephen D. Kasteler, Manuel G. Cosio, Anne Sturrock, Tom Huecksteadt, and John R. Hoidal

RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells
Am J Physiol Lung Cell Mol Physiol 294: L1094-L1101, 2008. First published April 4, 2008; doi:10.1152/ajplung.00318.2007 [Abstract] [Full Text] [PDF]  

Kurt Schwalm, Junko F. Stevens, Zeyu Jiang, Mark R. Schuyler, Ron Schrader, Scott H. Randell, Francis H. Y. Green, and Yohannes Tesfaigzi

Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects
Am J Physiol Lung Cell Mol Physiol 294: L1102-L1109, 2008. First published April 4, 2008; doi:10.1152/ajplung.00424.2007 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Raquel O. Nunes, Martina Schmidt, Gordon Dueck, Hoeke Baarsma, Andrew J. Halayko, Huib A. M. Kerstjens, Herman Meurs, and Reinoud Gosens

GSK-3/β-catenin signaling axis in airway smooth muscle: role in mitogenic signaling
Am J Physiol Lung Cell Mol Physiol 294: L1110-L1118, 2008. First published April 4, 2008; doi:10.1152/ajplung.00500.2007 [Abstract] [Full Text] [PDF]  

William E. Lawson, Peter F. Crossno, Vasiliy V. Polosukhin, Juan Roldan, Dong-Sheng Cheng, Kirk B. Lane, Thomas R. Blackwell, Carol Xu, Cheryl Markin, Lorraine B. Ware, Geraldine G. Miller, James E. Loyd, and Timothy S. Blackwell

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
Am J Physiol Lung Cell Mol Physiol 294: L1119-L1126, 2008. First published April 4, 2008; doi:10.1152/ajplung.00382.2007 [Abstract] [Full Text] [PDF]  

Beth Besecker, Shengying Bao, Barbara Bohacova, Audrey Papp, Wolfgang Sadee, and Daren L. Knoell

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia
Am J Physiol Lung Cell Mol Physiol 294: L1127-L1136, 2008. First published April 4, 2008; doi:10.1152/ajplung.00057.2008 [Abstract] [Full Text] [PDF]  

Petra Haberzettl, Roel P. F. Schins, Doris Höhr, Verena Wilhelmi, Paul J. A. Borm, and Catrin Albrecht

Impact of the FcII-receptor on quartz uptake and inflammatory response by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol 294: L1137-L1148, 2008. First published April 4, 2008; doi:10.1152/ajplung.00261.2007 [Abstract] [Full Text] [PDF]  

Robert Foronjy, Takwi Nkyimbeng, Alison Wallace, Jincy Thankachen, Yasunori Okada, Vincent Lemaitre, and Jeanine D'Armiento

Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin
Am J Physiol Lung Cell Mol Physiol 294: L1149-L1157, 2008. First published April 11, 2008; doi:10.1152/ajplung.00481.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

R. D. Nolen-Walston, C. F. Kim, M. R. Mazan, E. P. Ingenito, A. M. Gruntman, L. Tsai, R. Boston, A. E. Woolfenden, T. Jacks, and A. M. Hoffman

Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration
Am J Physiol Lung Cell Mol Physiol 294: L1158-L1165, 2008. First published March 28, 2008; doi:10.1152/ajplung.00298.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure and Video]  

Jane A. Madden, Mark W. Dantuma, Elena A. Sorokina, Dorothee Weihrauch, and Jack G. Kleinman

Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries
Am J Physiol Lung Cell Mol Physiol 294: L1166-L1173, 2008. First published March 28, 2008; doi:10.1152/ajplung.00375.2007 [Abstract] [Full Text] [PDF]  

Hongwei Yao, Indika Edirisinghe, Saravanan Rajendrasozhan, Se-Ran Yang, Samuel Caito, David Adenuga, and Irfan Rahman

Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice
Am J Physiol Lung Cell Mol Physiol 294: L1174-L1186, 2008. First published March 28, 2008; doi:10.1152/ajplung.00439.2007 [Abstract] [Full Text] [PDF]  

Rong Ji, Clement M. Lee, Linda W. Gonzales, Yi Yang, Mark O. Aksoy, Ping Wang, Eugen Brailoiu, Nae Dun, Matthew T. Hurford, and Steven G. Kelsen

Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A
Am J Physiol Lung Cell Mol Physiol 294: L1187-L1196, 2008. First published March 28, 2008; doi:10.1152/ajplung.00388.2007 [Abstract] [Full Text] [PDF]  

Patrícia Angeli, Carla M. Prado, Débora G. Xisto, Pedro L. Silva, Caroline P. Pássaro, Hugo D. Nakazato, Edna A. Leick-Maldonado, Milton A. Martins, Patricia R. M. Rocco, and Iolanda F. L. C. Tibério

Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation
Am J Physiol Lung Cell Mol Physiol 294: L1197-L1205, 2008. First published March 21, 2008; doi:10.1152/ajplung.00199.2007 [Abstract] [Full Text] [PDF]  

Kentaro Mizuta, Dingbang Xu, Yaping Pan, George Comas, Joshua R. Sonett, Yi Zhang, Reynold A. Panettieri, Jr., Jay Yang, and Charles W. Emala, Sr.

GABA_A receptors are expressed and facilitate relaxation in airway smooth muscle
Am J Physiol Lung Cell Mol Physiol 294: L1206-L1216, 2008. First published April 11, 2008; doi:10.1152/ajplung.00287.2007 [Abstract] [Full Text] [PDF]  

William D. Hardie, Cynthia Davidson, Machiko Ikegami, George D. Leikauf, Timothy D. Le Cras, Adrienne Prestridge, Jeffrey A. Whitsett, and Thomas R. Korfhagen

EGF receptor tyrosine kinase inhibitors diminish transforming growth factor--induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol 294: L1217-L1225, 2008. First published April 18, 2008; doi:10.1152/ajplung.00020.2008 [Abstract] [Full Text] [PDF]  

Koichiro Kamio, Tadashi Sato, Xiangde Liu, Hisatoshi Sugiura, Shinsaku Togo, Tetsu Kobayashi, Shin Kawasaki, Xingqi Wang, Lijun Mao, Youngsoo Ahn, Olaf Holz, Helgo Magnussen, and Stephen I. Rennard

Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture
Am J Physiol Lung Cell Mol Physiol 294: L1226-L1232, 2008. First published April 18, 2008; doi:10.1152/ajplung.00129.2007 [Abstract] [Full Text] [PDF]  

Yochai Adir, Lynn C. Welch, Vidas Dumasius, Phillip Factor, Jacob I. Sznajder, and Karen M. Ridge

Overexpression of the Na-K-ATPase ₂-subunit improves lung liquid clearance during ventilation-induced lung injury
Am J Physiol Lung Cell Mol Physiol 294: L1233-L1237, 2008. First published April 18, 2008; doi:10.1152/ajplung.00076.2007 [Abstract] [Full Text] [PDF]  

ShouWei Han, Jeffrey D. Ritzenthaler, Ying Zheng, and Jesse Roman

PPARβ/ agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-B signals
Am J Physiol Lung Cell Mol Physiol 294: L1238-L1249, 2008. First published April 4, 2008; doi:10.1152/ajplung.00017.2008 [Abstract] [Full Text] [PDF]  

Jing Huang, Pawel M. Kaminski, John G. Edwards, Albert Yeh, Michael S. Wolin, William H. Frishman, Michael H. Gewitz, and Rajamma Mathew

Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension
Am J Physiol Lung Cell Mol Physiol 294: L1250-L1259, 2008. First published April 4, 2008; doi:10.1152/ajplung.00069.2007 [Abstract] [Full Text] [PDF]  

Hieronymus W. H. van Hees, Yi-Ping Li, Coen A. C. Ottenheijm, Bingwen Jin, Cindy J. C. Pigmans, Marianne Linkels, P. N. Richard Dekhuijzen, and Leo M. A. Heunks

Proteasome inhibition improves diaphragm function in congestive heart failure rats
Am J Physiol Lung Cell Mol Physiol 294: L1260-L1268, 2008. First published April 18, 2008; doi:10.1152/ajplung.00035.2008 [Abstract] [Full Text] [PDF]  

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